Search for dissertations about: "CBFβ"

Found 2 swedish dissertations containing the word CBFβ.

2. 1. The hematopoietic transcription factor RUNX1 : a structural view

   Author : Stefan Bäckström; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; RUNX1; Runt domain; CBFβ; transcription factor; leukaemia; protein crystallography; anomalous diffraction; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; molekylärbiologi; Molecular Biology;

   Abstract : The malfunction of the transcriptional regulator RUNX1 is the major cause of several variants of acute human leukemias and its normal function is to regulate the development of the blood system in concert with other transcriptional co-regulators. RUNX1 belongs to a conserved family of heterodimeric transcription factors that share a conserved DNA binding domain, the Runt domain (RD), named after the first member of this group – Runt - found in Drosophila melanogaster. READ MORE

4. 2. Structure-function relationships of the human Runx1 transcription factor

   Author : Magnus Wolf-Watz; KTH; []
   Keywords : Runx1; Runt domain; CBFâ; transcription; leukemia; protein structure; protein dynamics;

   Abstract : Runx transcription factors contain a DNA-binding andtransactivating α-subunit and a β-subunit (CBFβ)that serves to increase the DNA binding affinity of theα-subunit. The DNA binding domain of Runx proteins isnamed the Runt homology domain (RD) after its strong sequencehomology to theDrosophilaprotein Runt. READ MORE