Search for dissertations about: "CBP"
Showing result 16 - 20 of 31 swedish dissertations containing the word CBP.
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16. Gene regulation by the glucocorticoid receptor : post-DNA binding mechanisms of transcriptional activation
Abstract : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the nuclear receptor family. The GR has important functions in cellular differentiation, development and metabolism in higher eukaryotes. READ MORE
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17. Expression and functional analysis of the SCA7 disease protein ataxin-7
Abstract : Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disease characterized by cerebellar ataxia and visual problems due to a progressive and selective loss of neurons within the cerebellum, brainstem and retina. The disease is caused by the expansion of a CAG repeat in the first coding exon of the SCA7 gene, resulting in an expanded polyglutamine domain in the N-terminal part of ataxin-7, a protein of unknown function. READ MORE
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18. Identification of natural activators of the nuclear receptor peroxisome proliferator-activated receptor : relevance to the pathogenesis of atherosclerosis
Abstract : Polyunsaturated fatty acids induce peroxisome proliferation. This phenomenon is mediated by the ligand-dependent transcription factor peroxisome proliferator-activated receptor (PPAR). This thesis is an investigation on the role of eicosanoids and oxidized products of linoleic acid for the activation of PPARs. READ MORE
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19. Protein Acetylation – A Multifunctional Regulator of TGF-β Signaling
Abstract : Transforming growth factor β (TGF-β) is a member of a large family of cytokines that regulate many crucial events in cells, including proliferation, differentiation, migration and apoptosis. Deregulated TGF-β signaling is associated with various forms of cancers and developmental disorders. READ MORE
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20. Novel treatment strategies and regulation of IgE-mediated allergic disease
Abstract : Allergic symptoms such as rhinoconjunctivitis, asthma or gastrointestinal symptoms, triggered by inhaled or ingested allergens cross-linking allergen-specific IgE on mast cells or basophils, are defined as IgE-mediated allergy. The major allergens from birch pollen (Bet v 1) and cat dander (Fel d 1) are two common allergens eliciting allergic disease. READ MORE