Search for dissertations about: "CCK receptor antagonists"

Showing result 1 - 5 of 9 swedish dissertations containing the words CCK receptor antagonists.

  1. 1. Effect of Cholecystokinin-B/Gastrin Receptor Antagonists on Rat Stomach ECL Cells

    Author : Xi-Qin Ding; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; vävnadskultur; histokemi; cytokemi; Histologi; tissue culture; histochemistry; gastrin; cholecystokinin CCK receptors; ECL cells; CCK-B gastrin receptor antagonists; histidine decarboxylase HDC ; histamine; pancreastatin; chromogranin A CGA ; gastric acid secretion.; cytochemistry; Histology; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : The histamine- and pancreastatin- containing ECL cells in the acid-producing mucosa of the rat stomach operate under the control of circulating gastrin. The present work examines how cholecystokinin (CCK)-B/gastrin receptors regulate the activity of the ECL cells. READ MORE

  2. 2. The cholecystokinin receptor family : molecular cloning and pharmacological characterization

    Author : Isabelle Nilsson; Dan Larhammar; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Cholecystokinin (CCK) and gastrin are hormones/neurotransmittors of the gastrointestinal tract and central nervous system. The receptors for gastrin and CCK are members of the G protein-coupled receptor family. The aim of this study was to clone and pharmacologically characterize vertebrate and invertebrate CCK receptors and splice variants. READ MORE

  3. 3. The Gastrin-ECL Cell Axis. Functional Aspects

    Author : Maria Björkqvist; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Pharmacological sciences; Calcium channels; CCK receptor antagonists; Misoprostol; Galanin; Somatostatin; Pancreastatin; Histamine; VIP; Gastrin; PACAP;

    Abstract : The ECL cells constitute a prominent endocrine cell population in the acid-producing part of the stomach. They are controlled by circulating gastrin released from G-cells in the antrum. In response to gastrin, they secrete histamine, that in turn stimulates the parietal cell to secrete acid. READ MORE

  4. 4. Peripherally administered choleocystokinin-8 increases neurotrophins in the brain

    Author : Paola Tirassa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NGF; BDNF; CCK-8; glutamate; GABA; CCK receptors; hypothamalus; hippocampus; Choline Acetyltransferase; fimibria-fornix transection; vagotomy; vagal stimulation; RT-PCR; ELISA;

    Abstract : The aim of this thesis was to test the hypothesis that the gastric hormone Cholecystokinin-8 (CCK-8) can modulate the production of Nerve Growth Factor (NGF) in the brain. NGF is the first discovered and the best characterized neurotrophic factor which plays a crucial role in the survival and development of basal forebrain cholinergic neurons (BFCN). READ MORE

  5. 5. On cholecystokinin-opioid interaction in the spinal dorsal horn following peripheral nerve injury and inflammation

    Author : Guilherme de Araújo Lucas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Cholecystokinin; Cholecystokinin receptors; Morphine; Spinal cord; Axotomy; Inflammation; Peptide release; Morphine tolerance; [my]-opioid receptor; Flexor reflex; Microdialysis;

    Abstract : The peptide cholecystokinin (CCK) antagonizes opioid-induced analgesia. Conversely, antagonists of CCK receptors enhance the analgesic effect of opioids. Together, these results support a role for CCK as an anti-opioid peptide in pain mechanisms. READ MORE