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Showing result 1 - 5 of 7 swedish dissertations matching the above criteria.

2. 1. Neuro-immune communication: role of the vagus nerve : an electrophysiological study

   Author : Violeta Bucinskaite; Karolinska Institutet; Karolinska Institutet; []
   Keywords : cholecystokinin; CCKA; CCKB; cytokines; IL-1[beta]; illness; nerve activity; NIDDM; OLETF; the vagus; vagotomy;

   Abstract : Defence mechanisms involve close interactions between the nervous and immune systems following an immune challenge. The vagal pathways which modulate major visceral functions under normal conditions are also important neural pathways for the transmission of information on peripheral conditions to the CNS. READ MORE

4. 2. Aspects on the psychopharmacology of cholecystokinin

   Author : Diana Radu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Cholecystokinin; brain; tripeptidyl-peptidase II; CCK receptors; schizophrenia; anxiety; stress; rat; monkey; human; pentagastrin; C-peptide; mRNA;

   Abstract : This thesis includes studies of the effect of mild stress on brain cholecystokinin (CCK), anatomy of markers for CCK-ergic transmission in the brain and the systemic effect of CCK receptor stimulation in a clinical test for anxiety and fear. CCK is a brain-gut peptide acting as a neurotransmitter in mammalian brain via CCKA (CCK1) and CCKB (CCK2) receptors. READ MORE

5. 3. Peripherally administered choleocystokinin-8 increases neurotrophins in the brain

   Author : Paola Tirassa; Karolinska Institutet; Karolinska Institutet; []
   Keywords : NGF; BDNF; CCK-8; glutamate; GABA; CCK receptors; hypothamalus; hippocampus; Choline Acetyltransferase; fimibria-fornix transection; vagotomy; vagal stimulation; RT-PCR; ELISA;

   Abstract : The aim of this thesis was to test the hypothesis that the gastric hormone Cholecystokinin-8 (CCK-8) can modulate the production of Nerve Growth Factor (NGF) in the brain. NGF is the first discovered and the best characterized neurotrophic factor which plays a crucial role in the survival and development of basal forebrain cholinergic neurons (BFCN). READ MORE

6. 4. Characterization of neuropeptide, monoamine, and amino acid release in the basal ganglia of the rat : neuronal dependence and reciprocal interactions

   Author : Zhi-Bing You; Karolinska Institutet; Karolinska Institutet; []
   Keywords : amino acids cholecystokinin dopamine dynorphin microdialysis morphineneostriatum rat substantia nigra.;

   Abstract : Functional interactions in the basal ganglia of rats were characterized with in vivomicrodialysis. The study was mainly focused on the dynorphin and cholecystokinin (CCK) systems. The extracellular levels of both dynorphin B and CCK were found in the pM range inthe neostriatum and substantia nigra under basal conditions. READ MORE

7. 5. Neuropeptide circuitries regulating food and water intake

   Author : Christian Broberger; Karolinska Institutet; Karolinska Institutet; []
   Keywords : agouti gene-related protein; anorexia mutation; arcuate nucleus; cholecystokinin; cocaine- and amphetamine-regulated transcript; coexistence; confocal microscopy; dorsal root ganglion; feeding; hypocretin; immunohistochemistry; in situ hybridization; melanin-concentrating hormone; nodose ganglion; nucleus tractus solitaxii; orexin; paraventricular nucleus; satiety; sensory neurones; pro-opiomelanocortin; vagus nerve;

   Abstract : An adequate supply of nutrients through food intake is critical for survival, as evidenced by disorders such as obesity and anorexia, which in the long run may be life-threatening. Feeding behaviour is ultimately controlled by interacting neuronal populations in the brain. READ MORE