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Showing result 1 - 5 of 23 swedish dissertations matching the above criteria.

  2. 1. Monocyte chemoattractant protein-1 and CC-chemokine receptor-2 in two different conditions related to atherosclerosis

    Author : Henrik Blomqvist; Linköpings universitet; []
    Keywords : atherosclerosis; hypercholesterolaemia; coronary artery disease; inflammation; MCP-1; CCR2; CRP; MEDICINE; MEDICIN;

    Abstract : Atherosclerosis is the leading cause of death in the industrialized parts of the world. The pathological process is characterised by increased lipid influx to the arterial wall due to elevated circulating levels of low density lipoprotein (LDL). LDL is oxidatively modified by reactive oxygen species forming oxLDL. READ MORE

  4. 2. Chemoattractant receptors in drug discovery : FPR2 and CCR2-two potential targets

    Author : Christina Kalderén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chemoattractants and chemoattractant receptors have many important functions in multicellular organisms, not least for their role in regulating migration of leukocytes. The receptors are also involved in many pathologies and they have, since they were cloned in the 1990ies, been regarded as attractive targets for development of drugs against cancer, viral infections, and inflammatory/autoimmune diseases. READ MORE

  5. 3. Genetic and immunological control of human myasthenia gravis

    Author : Xiaoyan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myasthenia Gravis MG ; beta2-adrenergic receptor beta2-AR ; CCR2; CCR5; cytolytic T lymphocyte-associated antigen-4 CTLA-4 ; OX40;

    Abstract : Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular junction. Because of the involvement of multiple factors in the disease, the overall aims of this thesis were to uncover the regulation of candidate genes and the possible cellular mechanisms involved in the immuno-regulation of human MG. READ MORE

  6. 4. Chemokine receptor expression and function in experimental autoimmune neuroinflammation

    Author : Sana Eltayeb; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neuroinflammatory lesions in the central nervous system (CNS) are characterized by the presence of leukocytes, mainly monocytes/macrophages, derived from the systemic compartment. We believe CC inflammatory chemokine receptors (CkRs), CCR1, CCR2 and CCR5 are prerequisite for controlling the migration of monocytes/macrophages into inflammatory foci. READ MORE

  7. 5. Immune responses in defined subgroups of patients with pulmonary sarcoidosis

    Author : Farah Idali; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Sarcoidosis; Löfgren s syndrome; cytokine; regulatory T cell; TIM molecule; TLR;

    Abstract : This thesis focuses on inflammatory responses in the airways of sarcoidosis patients. Sarcoidosis is a T helper 1-mediated inflammatory disease with unknown aetiology. HLA-DRB1*0301pos sarcoidosis patients often present with an acute form of disease, i.e. READ MORE