Search for dissertations about: "CCR5"
Showing result 11 - 15 of 64 swedish dissertations containing the word CCR5.
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11. Inflammation and neurodegeneration in mouse nervous system : experimental application
Abstract : Experimental autoimmune neuritis (EAN) is a CD4+ T cell mediated inflammatory autoimmune disease of peripheral nervous system (PNS) and shares many of clinical, immunological, electrophysiological and morphological characteristics of human Guillain-Barré syndrome (GBS). Hence, EAN is considered to represent a useful model for studying the pathogenesis and therapy of human GBS. READ MORE
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12. Immunomodulation and immunopathogenesis in autoimmune disease with emphasis on autoimmune neuritis and arthritis
Abstract : Experimental autoimmune neuritis (EAN) and arthritis are CD4+ T cell mediated autoimmune animal models for the study of immunomodulation and immunopathogenesis of human Guillain-Barré syndrome (GBS) and rheumatoid arthritis (RA). Inflammatory cell infiltration and cytokine production in the target organs are characteristic features of both diseases, suggesting a role of cytokine production in the pathogenesis. READ MORE
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13. Biological determinants of HIV infection : studies of viral evolution during disease progression in children and adults
Abstract : Coreceptor usage of primary HIV-1 isolates was analysed in relation to their biological phenotype and the severity of HIV-1 infection in the patient. The indicator cell lines, U87 glioma cells engineered to express CD4 and one of the chemokine receptors CCR1, CCR2b, CCR3, CCR5 or CXCR4, were infected with a panel of well-characterized primary HIV-1 isolates. READ MORE
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14. Amino acid predictors of HIV-1 coreceptor use in different subtypes and their application to antiretroviral treatment
Abstract : The human immunodeficiency virus type 1 (HIV-1) group M is responsible for the HIV pandemic and has great genetic variability. The main subtypes and circulating recombinant forms belonging to this group differ in their worldwide distribution, their disease progression patterns, as well as in their coreceptor use phenotype distributions. READ MORE
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15. The use of peptides for studying molecular events in HIV- and HSV-infections
Abstract : Synthetic peptides were used as tools in order to study various characteristic sof human immunodeficiency virus (HIV) and herpes simplex virus (HSV). Peptides were designed as multiple antigenic peptides (MAPs) and used as HIV vaccines in experimental animals. The included HIV epitopes were more immunogenic when immunized as MAPs than as a protein. READ MORE