Search for dissertations about: "CCR5"

Showing result 6 - 10 of 64 swedish dissertations containing the word CCR5.

  2. 6. Coreceptor usage and sensitivity to neutralization of HIV-1 and HIV-2

    Author : Yu Shi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; HIV-2; pathogenesis; neutralization; coreceptor usage; envelop sequence; glycosylation; U87.CD4 cells; GHOST 3 cells; CCR5; CXCR4;

    Abstract : The aim of this project was to study neutralization and coreceptor use in HIV-1 and HIV-2. The first step was to develop a simple and standardized assay for detection and quantification of HIV- 1 neutralizing activity in human sera. READ MORE

  4. 7. Studies on HIV-2 antibody mediated neutralisation, coreceptor usage and in vivo tropism

    Author : Andreas Mörner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-2; neutralising antibodies; V3; combinatorial library; phage display; Fab fragment; coreceptor; CCR5; CXCR4; HIV encephalitis; macrophages microglia;

    Abstract : Human immunodeficiency virus type 2 (HIV-2) is the second virus that causes AIDS in humans. It has a genetic identity with HIV-1 of 40-60% and similar genetic organisation and biological properties, but the two viruses are distinguished certain features. READ MORE

  5. 8. Genetic and immunological control of human myasthenia gravis

    Author : Xiaoyan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myasthenia Gravis MG ; beta2-adrenergic receptor beta2-AR ; CCR2; CCR5; cytolytic T lymphocyte-associated antigen-4 CTLA-4 ; OX40;

    Abstract : Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular junction. Because of the involvement of multiple factors in the disease, the overall aims of this thesis were to uncover the regulation of candidate genes and the possible cellular mechanisms involved in the immuno-regulation of human MG. READ MORE

  6. 9. Evolution of HIV-1 coreceptor use in relation to pathogenesis

    Author : Ingrid Karlsson; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; RANTES; higly active antiretroviral therapy; pathogenesis; lymphoid tissue; cehmokine receptor; biological phenotype; coreceptor; HIV-1; evolution;

    Abstract : HIV-1 uses the coreceptors CCR5 and/or CXCR4 in addition to CD4 to enter the host cell. CCR5-using HIV-1 (R5 phenotype) appears to transmit infection and usually dominates the early stages of disease. READ MORE

  7. 10. Dynamics of HIV coreceptors and their utilization by plasma and cerebrospinal fluid HIV-1 isolates

    Author : Ulf Karlsson; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : HIV-1 infection of CD4+ immune cells requires the assistance of cellular coreceptors. The regulation of these receptors is highly dynamic. In addition to the major coreceptors, CCR5 and CXCR4, several alternative coreceptors mediate entry for selected HIV isolates in vitro, although their role in vivo is yet to be established. READ MORE