Search for dissertations about: "CCR9"
Showing result 1 - 5 of 12 swedish dissertations containing the word CCR9.
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1. Chemokine Receptor CCR9: Studies on the Generation and Localization of Gut Tropic Lymphocytes
Abstract : Lymphocytes are important mediators of adaptive immune responses. Naive T lymphocytes circulate in the blood and lymph between different secondary lymphoid organs in search for their specific antigen. READ MORE
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2. Phenotype and function of intestinal CD103+ dendritic cells
Abstract : Mucosal tissues such as the intestine present an enormous surface area to the outside environment and are continually exposed to foreign antigens in food and microflora. Thus, the intestinal mucosa must must remain tolerant to these innocuous antigens while at same time be able to mount effective immune responses to pathogens. READ MORE
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3. EFFECTOR T CELL HOMING TO THE SMALL INTESTINAL MUCOSA
Abstract : The intestinal mucosa, including the intestinal epithelium and underlying lamina propria (LP), contains a large number of effector/memory T cells that are thought to play a central role in the generation and maintenance of mucosal immune responses and in maintaining mucosal integrity. The work in this thesis investigates the mechanisms regulating effector T cell recruitment to the small intestinal mucosa focusing on the role of chemokine receptors in this process. READ MORE
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4. Chemokines and Integrins in Lymphocyte Development and Localization
Abstract : The small intestine contains a large number of T lymphocytes within the single-layered epithelium that separates the gut lumen from the lamina propria. These intraepithelial T lymphocytes have potent cytolytic and immunoregulatory capacities, thought to be important for fighting infections, neoplastic growth, and sustaining epithelial integrity. READ MORE
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5. Expression and regulation of CCL25 and its role in T cell localization to and function within the small intestine
Abstract : Earlier studies have demonstrated an important role for the chemokine CCL25, and its receptor CCR9, in the generation of the small intestinal lymphocyte compartment. The work in this thesis was aimed at determining how CCL25 is regulated within the small intestinal mucosa, and what potential role it plays in T cell localization to and function within this site. READ MORE