Search for dissertations about: "CD28 analysis"

Showing result 1 - 5 of 16 swedish dissertations containing the words CD28 analysis.

  2. 1. Sentinel Node Biopsy in Breast Cancer : Clinical and Immunological Aspects

    Author : Jana de Boniface; Leif Bergkvist; Annika Håkansson; Omgo Nieweg; Uppsala universitet; []
    Keywords : Surgery; breast cancer; tumour immunology; sentinel node biopsy; CD3-zeta; CD28; Kirurgi;

    Abstract : The most important prognostic factor in breast cancer is the axillary lymph node status. The sentinel node biopsy (SNB) is reported to stage the axilla with an accuracy > 95 % in early breast cancer. Tumour-related perturbation of T-cell function has been observed in patients with malignancies, including breast cancer. READ MORE

  4. 2. Selection and use of affinity proteins developed by combinatorial engineering

    Author : Kristofer Sandström; KTH; []
    Keywords : phage display; combinatorial; selection; cd28; cllulosome; cellulose;

    Abstract : In affinity protein biotechnology the selective bindingbetween a chosen protein and an interacting biomolecule isutilized for a variety of applications including bioseparation,detection and therapy. Traditionally, affinity proteinsrecruited for such applications have been derived from naturalproteins or immunoglobulins generated via immunization routes. READ MORE

  5. 3. Human intestinal T lymphocytes : a comparative analysis of phenotype and function in normal and inflamed mucosa

    Author : Silvia Melgar; Nadine Cerf-Bensussan; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestinal mucosa; intraepithelial lymphocyte; lamina propria lymphocyte; γδ T cell; regulatory T cell; cytotoxicity; cytokine; basal lymphoid aggregate; ulcerative colitis; Crohn s disease;

    Abstract : The epithelial lining of the gut must allow immediate contact with beneficial components as nutrients and normal microflora. At the same time it runs the constant risk of attack from pathogenic microbes and noxious agents. READ MORE

  6. 4. Studies of molecular events during peripheral B cell differentiation

    Author : Jens Wrammert; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; B cells; Differentiation;

    Abstract : This thesis focuses on molecular changes occuring during terminal B cell differentiation as well as on somatic hypermutation and the generation and maintenance of B cell memory. During T cell dependent immune responses the average affinity for the eliciting antigen increases with time. READ MORE

  7. 5. Immunopathogenesis and nasal tolerance in experimental autoimmune myasthenia gravis

    Author : Fu-Dong Shi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Myasthenia gravis (MG) is a classical antibody-mediated autoimmune disease of the neuromuscular junction. Experimental autoimmune myasthenia gravis (EAMG), can be induced in susceptible rat or mouse strains by immunization with acetylcholine receptor (AChR) in complete Freund's adjuvant (CFA). READ MORE