Search for dissertations about: "CD3ζ"

Found 4 swedish dissertations containing the word CD3ζ.

  2. 1. Functional studies of candidate genes contributing to type 1 diabetes in the NOD mouse

    Author : Marie Lundholm; Dan Holmberg; Vivianne Malmström; Umeå universitet; []
    Keywords : Type 1 Diabetes; NOD mouse; CTLA-4; Ctex; CD3ζ; apoptosis; Idd6; Lrmp; medicinsk genetik; Medical Genetics;

    Abstract : Type 1 Diabetes (T1D) is an autoimmune disorder caused by both genetic and environmental factors. The non-obese diabetic (NOD) mouse is one of the best and most commonly studied animal models for T1D. This mouse strain spontaneously develops diabetes through a process that closely resembles the human pathogenesis. READ MORE

  4. 2. Studies on neuronal signaling in the hippocampus related to development, pathogenesis and treatment of mood disorders

    Author : Nermin Sourial-Bassillious; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hippocampus;

    Abstract : The hippocampus is a central organ in the brain which is interconnected with different cortical regions and plays an important role in memory and learning processes. The anatomical position of the hippocampus together with the special sensitivity of its neurons renders it vulnerable to brain injury. READ MORE

  5. 3. Defining the potential of mesothelin-directed CAR T cells for the treatment of ovarian cancer

    Author : Esther Schoutrop; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chimeric antigen receptor (CAR) T cells have revolutionized the field of immunotherapy, by redirecting T cell specificity and effector functions. Co-stimulation has proven to be crucial for therapeutic effectiveness of CAR T cells and remarkable clinical response rates have been achieved with second generation CD19-directed CAR T cells containing either a CD28 or 4-1BB co-stimulatory domain for the treatment of B cell malignancies. READ MORE

  6. 4. Cellular and personalized therapies in multiple myeloma with special emphasis on retargeted natural killer cells

    Author : Maria Karvouni; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple myeloma (MM) is a clonal plasma cell malignancy accounting for approximately 10% of all hematological cancer cases. Despite considerable advances in MM management, which led to exceptional response and survival rates, patients still experience relapse and cure remains elusive. READ MORE