Search for dissertations about: "CD3 analysis"

Showing result 1 - 5 of 35 swedish dissertations containing the words CD3 analysis.

  2. 1. Sentinel Node Biopsy in Breast Cancer : Clinical and Immunological Aspects

    Author : Jana de Boniface; Leif Bergkvist; Annika Håkansson; Omgo Nieweg; Uppsala universitet; []
    Keywords : Surgery; breast cancer; tumour immunology; sentinel node biopsy; CD3-zeta; CD28; Kirurgi;

    Abstract : The most important prognostic factor in breast cancer is the axillary lymph node status. The sentinel node biopsy (SNB) is reported to stage the axilla with an accuracy > 95 % in early breast cancer. Tumour-related perturbation of T-cell function has been observed in patients with malignancies, including breast cancer. READ MORE

  4. 2. Gene expression analysis of Tec family kinases in B- and T-lymphocytes

    Author : K Emelie M Blomberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The microarray technology is a powerful tool used in many different research areas. The technique has been around for more than a decade and has revolutionized the molecular biology field. In this thesis the Affymetrix GeneChip® arrays were used to study the transcriptomes of Tec family kinase mutant mouse models. READ MORE

  5. 3. Human intestinal T lymphocytes : a comparative analysis of phenotype and function in normal and inflamed mucosa

    Author : Silvia Melgar; Nadine Cerf-Bensussan; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestinal mucosa; intraepithelial lymphocyte; lamina propria lymphocyte; γδ T cell; regulatory T cell; cytotoxicity; cytokine; basal lymphoid aggregate; ulcerative colitis; Crohn s disease;

    Abstract : The epithelial lining of the gut must allow immediate contact with beneficial components as nutrients and normal microflora. At the same time it runs the constant risk of attack from pathogenic microbes and noxious agents. READ MORE

  6. 4. Cytokines in rheumatoid arthritis

    Author : Ann-Kristin Ulfgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Rheumatoid arthritis; Synovitis; Immunohistochemistry; Digital image analysis; Cytokine Therapy; TNF neutralisation; Arthroscopy;

    Abstract : Rheumatoid arthritis (RA) is a chronic systemic disease characterised by inflammation in several joints. Cytokines appear to be important as both disease promoting and disease- suppressing mediators in the disease. READ MORE

  7. 5. Cytogenetic studies of normal kidney tissue and renal cell carcinoma

    Author : Peter Elfving; Malmö (Abrahamsson) Urologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; Klinisk genetik; Clinical genetics; nonneoplastic kidney tissue; renal cell carcinoma; trisomy 7; Cytogenetics; FISH; oncology; cancerology; Cytologi; onkologi; cancer;

    Abstract : In the present thesis normal kidney tissue and renal cell carcinoma (RCC) were studied by cytogenetic and fluorescence in situ hybridization (FISH) methods to investigate chromosomal aberrations. In the first study, 4 samples of nonneoplastic kidney tissue were cultured for cytogenetic analysis and trisomy 7 was found in all cases in 3-15% of the cells. READ MORE