Search for dissertations about: "CD40-stimulation"

Found 3 swedish dissertations containing the word CD40-stimulation.

2. 1. Regulation of growth, differentiation and survival of B-chronic lymphocytic leukemia cells

   Author : Ola Söderberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; B-CLL; B cells; IL-2; IL-4; IL-10; IL-15; CD40-stimulation; SAC; Thioredoxin; proliferation; differentiation; survival; in vitro; EBV; Patologi; Pathology; Patologi; Pathology; patologi;

   Abstract : Chronic lymphocytic leukemia of B cell type (B-CLL) is the most commonform of leukemia in the Western countries. The signals regulating theexpansion of the B-CLL clone in vivo is yet far from being fully understood. READ MORE

4. 2. Early events of EBV mediated B cell transformation

   Author : Katja Pokrovskaja; Karolinska Institutet; Karolinska Institutet; []
   Keywords : EBV; EBNA; p53; LMP-1; BL; GC; pNDCFs;

   Abstract : Epstein-Barr virus (EBV) efficiently immortalizes B cells in vitro leading to the establishment of lymphoblastoid cell lines (LCLs). Genes encoding RB and p53 are frequently deleted or mutated in human tumors. EBV immortalized LCLs, however, retain both genes in their wild type state. READ MORE

5. 3. Regulation of germline transcription in the immunoglobulin heavy chain locus

   Author : Jurga Laurencikiene; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : During an immune response, activated B cells develop into high rate immunoglobulin (Ig) secreting plasma cells. They also switch from production of IgM to IgG, IgA or IgE. Specific isotypes of antibodies have functional and structural features that make them particularly well suited to defend against different types of pathogens. READ MORE