Search for dissertations about: "CD40"
Showing result 11 - 15 of 89 swedish dissertations containing the word CD40.
-
11. Signalling mechanisms in B cell differentiation: Studies on specific human immune response in vitro
Abstract : We need to understand the major signalling events in human B cell differentiation in order to be able to regulate the generation of human antigen specific antibodies. This study has focused on the signalling mechanisms involved in generation of germinal centre reaction and secretion of specific antibodies by human B cells, using different in vitro immunisation technologies. READ MORE
-
12. Adenovirus-mediated CD40 Ligand Immunotherapy of Prostate and Bladder Cancer
Abstract : Cancer immunotherapy aims at reversing the immunosuppressive tumor environment and enhancing anti-tumor immunity. This thesis comprises studies on murine models for prostate (TRAMP-C2) and bladder (MB49) cancer with the aim to explore if the introduction of an adenoviral vector expressing CD40 ligand (AdCD40L) can induce anti-tumor immune responses. READ MORE
-
13. Antibody-based immunotherapy of cancer : From optimization to novel approaches
Abstract : Antibody immunotherapy is a successful therapeutic approach to treat cancer. The overall aim of this thesis is to investigate the mechanisms of antibody-based immunotherapies and the role of the tumor microenvironment in mediating the anti-tumor immune response, in order to aid the development of improved immunotherapies for cancer patients. READ MORE
-
14. Antibody- and Peptide-based Immunotherapies : Proof-of-concept and safety considerations
Abstract : The aim of cancer immunotherapy is to eradicate tumours by inducing a tumour-specific immune response. This thesis focuses on how antibodies and peptides can improve antigen presentation and the subsequent tumour-specific T cell response. Tumour recognition by the immune system can be promoted through delivery of antigen in the form of a vaccine. READ MORE
-
15. Regulation of growth, differentiation and survival of B-chronic lymphocytic leukemia cells
Abstract : Chronic lymphocytic leukemia of B cell type (B-CLL) is the most commonform of leukemia in the Western countries. The signals regulating theexpansion of the B-CLL clone in vivo is yet far from being fully understood. READ MORE