Search for dissertations about: "CD44"

Showing result 6 - 10 of 66 swedish dissertations containing the word CD44.

  2. 6. Hyaluronan and the receptor CD 44 in the heart and vessels : a study in normal and pathological conditions

    Author : Martin Hellström; Anna Engström-Laurent; Bengt Johansson; Lena Jonasson; Umeå universitet; []
    Keywords : hyaluronan; CD44; heart; Rat; cardiac hypertrophy; artery; vein; human; Medicine; medicin;

    Abstract : Tissues are not solely composed of cells. The extracellular matrix is important for the cell well-being and cell-cell communication. The glycosaminoglycan hyaluronan (HYA) is a widely distributed extracellular matrix (ECM) component. READ MORE

  4. 7. SIGNALING MECHANISMS IN SEPSIS-INDUCED IMMUNE DYSFUNCTION

    Author : Zirak Hasan; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; abdominal sepsis; neutrophil; lung; chemokines; infection; T-cells; CD44; Rho-kinase; isoprenylation;

    Abstract : Sepsis and subsequent organ failure remain the major cause of mortality in intensive care units in spite of significant research efforts. The lung is the most vulnerable organ affected by early hyper-inflammatory immune response in septic patients. READ MORE

  5. 8. Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence

    Author : Jacob Engellau; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; growth pattern; time-dependence; P-glycoprotein Pgp ; CD44; β-catenin; cyclin A; bcl-2; p53; Ki-67; immunohistochemistry IHC ; whole-tumor sections; tissue microarray TMA ; Soft tissue sarcoma; prognostic factors; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

    Abstract : In adult soft tissue sarcoma (STS) of the extremities and trunk wall, improved prognostic factors are needed to identify patients at high-risk for metastasis. Various factors are included in the many prognostic systems currently in use and the prognostic value of immunohistochemical (IHC) expression of biological markers is unclear. READ MORE

  6. 9. HIF-dependent Signaling Pathways in Cancer

    Author : Elinn Johansson; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Hypoxia; ccRCC; glioma; CD44; Notch1; reactive astrocytes;

    Abstract : The cellular response to hypoxia, primarily orchestrated by hypoxia-inducible factors (HIFs; mainly HIF-1α and HIF-2α), is at the center of several signaling pathways conferring aggressive tumor behavior. HIFs may be crucially involved in tumor initiation, as seen in clear cell renal cell carcinoma, as well as maintenance of resistance cancer stem cell phenotypes, as observed in glioma. READ MORE

  7. 10. Hyaluronan and Renal Fluid Handling : Studies during Normal and Pathological Conditions of Renal Function

    Author : Viktoria Göransson; Mats Rundgren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; CD44; gerbils; hyaluronan; ischemia-reperfusion; kidney; osmolality; oxygen tension; rat; renomedullary interstitial cells; water; Cellbiologi; Cell biology; Cellbiologi; Physiology; fysiologi;

    Abstract : The kidney is the major organ responsible for the regulation of the composition and volume of the body fluids, which is essential for homeostasis. The glycosaminoglycan hyaluronan (HA), with extreme water-binding capacity, is present in the interstitium of the kidney with a heterogenous distribution. READ MORE