Search for dissertations about: "CD62L"

Showing result 1 - 5 of 12 swedish dissertations containing the word CD62L.

  1. 1. The role of granulocyte antibodies in monocyte and granulocyte activation

    Author : Agneta Wikman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ANCA; adhesion molecules; CD11b; CD62L; granulocyte antibodies; granulocytes; monocytes; systemic vasculitis;

    Abstract : Granulocytes and monocytes are important cells during the first phase of inflammation. They are activated and recruited from the blood vessels to inflammatory sites via the regulation of receptors involved in adhesion to endothelium. READ MORE

  2. 2. Genetic and immunological studies of DCIR in inflammatory arthritis

    Author : Carina Eklöw; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) is a clinically heterogeneous condition with a wide spectrum of clinical manifestations, great variability in severity and disease progression rate. Thus, it is important to define new genetic and immunological markers, which could be useful for sub-grouping of RA, and for new targeted therapies. READ MORE

  3. 3. Modulation of adhesion molecules on leukocytes during clinical and experimental hemodialysis : endothelial cell interacions

    Author : Pia Thylén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adhesion; adhesion molecules; complement; endothelial cells; hemodialysis; integrins; interleukin; leukocytes; selectins.;

    Abstract : In patients on hemodialysis the sequential steps required for adhesion molecule mediated adherence of leukocytes to endothelial cells are unphysiologically disrupted since cell activation with subsequent alterations in adhesion molecule phenotypes takes place in the extracorporeal circuit far away from the respective endothelial cell ligand. The aims of the present investigations were to study the changes in adhesion molecule phenotypes on inflammatory cells induced by clinical and experimental hemodialysis and the consequences with regard to the capacity of the cells to adhere to endothelial cells. READ MORE

  4. 4. Allergic rhinitis and intralymphatic vaccination : immune response and tolerance

    Author : Eric Hjalmarsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The overall goal of this thesis was to study novel immunological mechanisms for the development of pollen-induced allergic rhinitis (AR) and to evaluate the clinical response in combination with immunological changes in AR patients treated with intralymphatic immunotherapy (ILIT). In paper I, an increased fraction of neutrophils were detected in the nasal mucosa of AR patients compared with healthy controls. READ MORE

  5. 5. Innovative approaches to study basophil function in inflammation

    Author : Zenib Aljadi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Basophils are circulating granulocytes. They are very rare and represent less than 1% of peripheral blood leukocytes. Basophils connect the innate and adaptive immune responses by the secretion of a variety of immune-mediators involved in the pathogenesis of many inflammatory diseases mainly allergic reactions and autoimmune diseases. READ MORE