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Showing result 1 - 5 of 13 swedish dissertations matching the above criteria.
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1. The role of granulocyte antibodies in monocyte and granulocyte activation
Abstract : Granulocytes and monocytes are important cells during the first phase of inflammation. They are activated and recruited from the blood vessels to inflammatory sites via the regulation of receptors involved in adhesion to endothelium. READ MORE
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2. Genetic and immunological studies of DCIR in inflammatory arthritis
Abstract : Rheumatoid arthritis (RA) is a clinically heterogeneous condition with a wide spectrum of clinical manifestations, great variability in severity and disease progression rate. Thus, it is important to define new genetic and immunological markers, which could be useful for sub-grouping of RA, and for new targeted therapies. READ MORE
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3. Composition and maintenance of skin resident T-cells in health and disease
Abstract : Tissue-resident memory T cells (TRM) reside in healthy skin at sites of previous infections. Upon re-infection, TRM cells rapidly respond by initiating tissue inflammation and exert effector functions to eliminate pathogens. TRM cells are potent effector cells and as such, they are key players in focal inflammatory skin diseases. READ MORE
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4. Modulation of adhesion molecules on leukocytes during clinical and experimental hemodialysis : endothelial cell interacions
Abstract : In patients on hemodialysis the sequential steps required for adhesion molecule mediated adherence of leukocytes to endothelial cells are unphysiologically disrupted since cell activation with subsequent alterations in adhesion molecule phenotypes takes place in the extracorporeal circuit far away from the respective endothelial cell ligand. The aims of the present investigations were to study the changes in adhesion molecule phenotypes on inflammatory cells induced by clinical and experimental hemodialysis and the consequences with regard to the capacity of the cells to adhere to endothelial cells. READ MORE
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5. Allergic rhinitis and intralymphatic vaccination : immune response and tolerance
Abstract : The overall goal of this thesis was to study novel immunological mechanisms for the development of pollen-induced allergic rhinitis (AR) and to evaluate the clinical response in combination with immunological changes in AR patients treated with intralymphatic immunotherapy (ILIT). In paper I, an increased fraction of neutrophils were detected in the nasal mucosa of AR patients compared with healthy controls. READ MORE