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Showing result 1 - 5 of 42 swedish dissertations matching the above criteria.

  2. 1. The impact of Wnt5a signaling and tumor associated macrophages in breast cancer

    Author : Catharina Hagerling; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Wnt5a; E-cadherin; B-catenin; migration; invasion; turnor associated macrophages; CD163; CD68; turnor stroma;

    Abstract : Breast cancer is the most common cancer among women worldwide with approximately 1.150.000 new cases each year and accounting for over 400.000 deaths per year. READ MORE

  4. 2. Healing of endosseous implants with different surface characteristics in grafted and non-grafted bone : clinical and experimental studies

    Author : Måns Jungner; Stefan Lundgren; Malou Hultcrantz; Carina Lundqvist; Peter Nilsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dental implants; surface characteristics; bone graft; maxillary sinus; implant survival; oxidized surface; turned surface; sinus membrane elevation; bone formation; macrophages; osteocalcin; osteopontin; CD68; odontologi; Odontology;

    Abstract : Aims: This study uses radiological and clinical evaluations of the healing of endosseous titanium implants presented with different surface characteristics in the clinical situation (paper I-III) and experimentally to describe the early bone healing in maxillary sinus membrane elevation with and without the use of grafting material (paper IV).Material and methods: In paper I, 136 patients were treated with 394 dental implants – 199 were oxidized titanium implants (Nobel Biocare TiUnite) and 195 were turned titanium surface implants (Nobel Biocare Mark III). READ MORE

  5. 3. Immunologic Markers in the Tumor Microenvironment of Classical Hodgkin Lymphoma

    Author : Alex R. Gholiha; Gunilla Enblad; Rose-Marie Amini; Peter Hollander; Gustaf Hedström; Arjan Diepstra; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor microenvironment; immunohistochemistry; immune checkpoints; Plasma cells; IL-6 cytokine; Proteomics; CD47.;

    Abstract : In classical Hodgkin lymphoma (cHL), cytokine regulation and cellular composition of the tumor microenvironment (TME) is crucial for tumor cell survival. In paper I, we examined the presence of CD138+ plasma cells and IgG4+ plasma cells in diagnostic cHL biopsies with immunohistochemistry (IHC). READ MORE

  6. 4. Oral chronic Graft-versus-host disease : clinical and pathological staging

    Author : Victor Tollemar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Allogenic hematopoietic cell transplantation (HCT) is a curative treatment for many patients with immune- hematopoietic disorders, mainly hematopoietic cancers as leukaemia. Chronic Graft-versus-Host Disease (cGVHD) is a major long-term complication, associated with mortality and morbidity following allogenic HCT. READ MORE

  7. 5. Novel markers for smooth muscle cell modulation in vascular injury and disease

    Author : Urszula Rykaczewska; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Smooth muscle cells (SMCs) are major constituents of the vascular wall, indispensable for basic physiological functions of a healthy vessel, such as regulating vascular tone and blood pressure, but also critical during disease development. With remarkable plasticity, SMCs act as early responders to vessel wall injury, where by activating molecular mechanisms, including phenotypic modulation and transdifferentiation, they counteract detrimental stimuli and aim to restore vascular homeostasis. READ MORE