Search for dissertations about: "CD8 cytotoxic T cells"

Showing result 1 - 5 of 102 swedish dissertations containing the words CD8 cytotoxic T cells.

  2. 1. Approaches to analyses of cytotoxic cells. And studies of their role in H. pylori infection

    Author : Josef Azem; Göteborgs universitet; []
    Keywords : Helicobacter pylori; mucosal immunology; stomach; duodenum; asymptomatic; duodenal ulcer; gastric adenocarcinoma; NK cells; T cells; B cells; dendritic cells; cytotoxic;

    Abstract : Helicobacter pylori infection causes chronic gastritis that may progress to peptic ulcers or gastric adenocarcinoma and thereby cause major world-wide health problems. Previous studies have shown that CD4+ T cells and the production of the cytokine IFN- × are important components of the immune response to H. pylori in humans. READ MORE

  4. 2. Adoptive T Cell Therapy of Viral Infection and Cancer : Ex vivo Expansion of Cytomegalovirus- and Prostate Antigen-specific T Cells

    Author : Björn Carlsson; Magnus Essand; Thomas Tötterman; Malcolm Brenner; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Immunotherapy; Adoptive T cell therapy; Dendritic cell; T cell; Tetramer; Cytomegalovirus; Transplantation; pp65; Prostate cancer; TARP; Prostate antigens; Immunologi; Immunology; Immunologi;

    Abstract : The main focus of my thesis has been to develop protocols for generating antigen-specific cytotoxic T lymphocytes (CTLs) and T helper cells (TH) for adoptive transfer to treat cytomegalovirus (CMV) disease and prostate cancer. CMV viremia is a severe complication in immunocompromised stem cell transplanted patients. READ MORE

  5. 3. Infection induced chronic inflammation and it's association with prostate cancer initiation and progression

    Author : Sabina Davidsson; Ove Andrén; Bo Söderquist; Jennifer Rider; Gisela Helenius; Jan-Erik Damber; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; chronic inflammation; CD4 helper T cells; CD8 cytotoxic T cells; regulatory T cells; Propionibacterium acnes; Medicine; Medicin;

    Abstract : An association between cancer development and inflammation has long been suggested. Approximately 20% of all human cancers in adults are assumed to result from chronic inflammation. The aim of this thesis was to investigate if infection-induced chronic inflammation plays a role in prostate carcinogenesis. READ MORE

  6. 4. Peripheral immunity in patients with autoimmune endocrine diseases and the influence of physiological adaptions during pregnancy

    Author : Louise Magnusson; Per-Ola Carlsson; Rosaura Casas; Ola Winqvist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Hashimoto´s thyroiditis; Graves´ disease; autoimmune Addison´s disease; antigen-presenting cells; B cells; non-classical monocytes; NK cells; memory CD8 T cells; CDCP1; SLAMF1; inflammation; lymphocyte activation; pregnancy; β-cell function; C-peptide; plasma proteome; prolactin; prokineticin-1; glucagon; oral glucose tolerance test; mass cytometry; proximity extension assay; Medicinsk vetenskap; Medical Science; Klinisk immunologi; Clinical Immunology; Endocrinology and Diabetology; Endokrinologi och Diabetologi; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Type 1 diabetes (T1D), Hashimoto’s thyroiditis (HT), Graves’ disease (GD), and autoimmune Addison’s disease (AD) appear to share immunogenetic mechanisms. This idea is not novel, as “autoimmune tautology” is an established concept. READ MORE

  7. 5. Immune maturation in early childhood and the influence of herpesvirus infections

    Author : Ebba Sohlberg; Eva Sverremark-Ekström; Eleanor Riley; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Immune differentiation; monocytes; NK cells; B cells; T cells; Epstein-Barr virus; EBV; cytomegalovirus; CMV; IFN-γ; immunologi; Immunology;

    Abstract : The quality of immune responses develops from birth into adulthood and in the context of the host microbial environment. The aim of this work was to study immune maturation during childhood, and how this process can be affected by the common herpesviruses; Epstein-Barr virus (EBV) and cytomegalovirus (CMV). READ MORE