Search for dissertations about: "CD8"

Showing result 6 - 10 of 411 swedish dissertations containing the word CD8.

2. 6. The dimensions of human and murine CD8 T lymphocyte diversity

   Author : Anthonie Johan Zwijnenburg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The adaptive immune system generates and maintains a pool of CD8+ T cells with an almost limitless specificity with the purpose of maintaining homeostasis. Upon antigen encounter, CD8+ T cells undergo functional diversification and give rise to daughter cells. READ MORE

4. 7. Leucine-rich repeats and immunoglobulin-like domain (LRIG) proteins : possible prognostic markers in vulvar squamous cell carcinoma, endometrial carcinoma, and oropharymgeal squamous cell carcinoma

   Author : Husam Oda; David Lindquist; Eva Lundin; Ulrika Ottander; Kristina Stefansson; Kate Cuschieri; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vulvar squamous cell carcinoma; endometrial carcinoma; oropharyngeal squamous cell carcinoma; LRIG1-3; HPV; LMO7; HPV-driven; non-HPV-driven; prognosis; overall survival; disease-free survival; p53; Ki-67; CD8 TILs; CD44.; Pathology; patologi;

   Abstract : The human leucine-rich repeats and immunoglobulin-like domain (LRIG) gene family comprises three genes, LRIG1, LRIG2 and LRIG3, which encode the LRIG1, LRIG2 and LRIG3 proteins, respectively. Previous stidies have revealed the different prognostic roles of these proteins in different cancers, and it has been shown that LRIG1 functions as a tumour suppressor in certain cancers via its negative regulation of several receptor tyrosine kinases. READ MORE

5. 8. Beta-chemokine and CD8+ T-cell noncytotoxic anti-HIV/SIV activity

   Author : Raija Ahmed; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : A small number of individuals remain uninfected despite repeated exposure to HIV. A number of viral and host factors are thought to account for this resistance. The cell-mediated immune response is likely to be important in controlling HIV/SIV infections. READ MORE

6. 9. Human intraepithelial lymphocytes : a comparative study of phenotype, morphology, and functional properties of intraepithelial lymphocytes in gut and oral mucosa

   Author : Carina Lundqvist; Marie-Louise Hammarström; Sten Hammarström; Per Brandtzaeg; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intraepithelial lymphocytes; alimentary tract; intestinal epithelium; gut luminal antigens; gingiva; γδ T cells; immunoelectron microscopy; cytokine mRNA; RT-PCR; extrathymic T cell maturation; RAG-1; periodontitis; mucosal immune system; CD4-CD8- αβ T cells; CD8 γδ T cells;

   Abstract : Human intraepithelial lymphocytes (IEL) constitute a unique cell population situated in the first line of defense of the alimentary tract. Here they are continuously exposed to a massive antigenic load of high complexity. However, different conditions prevail along the alimentary tract. READ MORE

7. 10. CD8+ T cell specificity in thymic selection and in the recognition of antigen

   Author : Johan Sandberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : T cell; specificity; MHC class 1; selection; tolerance;

   Abstract : Specificity mediated by the T cell receptor (TCR) is of fundamental importance for the ability of T cells to function, and regulate humoral immunity and effector mechanisms of the innate immune system. T cells recognize composite molecules consisting of products of the major histocompatibility complex (MHC) class I or class 11 loci, in complex with a short peptide fragment derived from endogenous or antigenic proteins. READ MORE