Search for dissertations about: "CD9"

Showing result 1 - 5 of 12 swedish dissertations containing the word CD9.

  2. 1. Regulation of Hematopoietic Stem Cells

    Author : Emma Rörby; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; hematopoietic stem cells; hematopoietic stem cell expansion; cord blood; transforming growth factor beta; Smad signaling; pigment epithelium derived factor; CD9;

    Abstract : This thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate new HSCs. READ MORE

  4. 2. Early fate decisions in hematopoietic stem and progenitor cells. Through the lens of genomic and functional assays

    Author : Fatemeh Safi; Avdelningen för molekylär hematologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; HSCs; singel cell sc ; scRNA-seq; scATAC-seq; CD9; Aging;

    Abstract : Hematopoietic stem cells (HSCs) are rare cells on top of the differentiation hierarchy of hematopoiesis. HSCs are unique in their combined capacity to differentiate into all mature blood lineages and self-renew to maintain the HSC pool. READ MORE

  5. 3. Cell biological mechanisms and activity markers of eosinophils in relation to allergic inflammation

    Author : Eva C Fernvik; Karolinska Institutet; Karolinska Institutet; []
    Keywords : allergic inflammation; CD9; CD11b; EG2; eosinophils; flow cytometry; FOG-method;

    Abstract : It is becoming increasingly apparent that the pathogenesis of respiratory allergic diseases, including asthma and allergic rhinitis, is closely linked to the presence of chronic inflammation. One of the leading actresses in the allergic inflammatory process is the eosinophil granulocyte. READ MORE

  6. 4. Particle Transcytosis Across the Human Intestinal Epithelium : Model Development and Target Identification for Improved Drug Delivery

    Author : Elisabet Gullberg; Per Artursson; Barry Hirst; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; M-cell; FAE; Peyer´s patches; oral vaccination; uptake; endocytosis; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : The use of nano- and micro-particulate carriers as delivery systems for oral vaccines has been under investigation for several decades. Surprisingly little is known of their uptake in the human intestine, despite the fact that substantial improvement is required to achieve adequate immune responses in man after oral administration. READ MORE

  7. 5. Molecular dissection of B-lymphocyte signalling using expression profiling

    Author : Jessica M Lindvall; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Btk; B-lymphocyte; gene expression profiling; signal transduction;

    Abstract : Gene expression profiling and bioinformatics have emerged into playing a large and diverse role in many aspects of both the clinical and molecular research. These two approaches have in this thesis work been used in combination in order to shed light to the role of Bruton's tyrosine kinase (Btk) in B-lymphocyte development and signal transduction. READ MORE