Search for dissertations about: "CDK"

Showing result 1 - 5 of 43 swedish dissertations containing the word CDK.

  1. 1. Growth control mechanisms in normal and neoplastic mammalian cells

    Author : Mozhgan Afrakhte; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; PDGF-AA; TGF-beta; Inhibitory SMADs; Growth inhibition; CDK; CKI; Cdc25A; Genetik; Clinical genetics; Klinisk genetik; Genetics; genetik;

    Abstract : The main theme of the studies presented in this thesis is, the growth control mechanisms whose loss in normal cells predispose to or cause cancer. The balance between growth inhibitory and stimulatory mechanisms is crucial for the development and maintenance of a normal animal. READ MORE

  2. 2. Regulation of CDK dephosphorylation in mitotic entry

    Author : Arne Lindqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Cell cycle progression is orchestrated by the activity of a Cyclin dependent kinase (Cdk) in complex with a Cyclin. The key regulator of early mitotic events is the Cyclin B1/Cdk1 complex. In G2, Cyclin B1/Cdk1 is kept inactive by phosphorylation in the active site of Cdk1. READ MORE

  3. 3. p57Kip2, a glucocorticoid-induced CDK inhibitor, involved in cell proliferation, apoptosis and differentiation

    Author : Magnus Samuelsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; p57Kip2 ; g lucocorticoids; cell cycle; apoptosis; lung development; transcriptional regulation;

    Abstract : Glucocorticoids (GCs), are steroid hormones with several important physiological implications, of which some are connected with the ability of GCs to inhibit cell proliferation. Although GC treatment normally accumulates cells in the GI phase of the cell cycle, the mechanisms behind this phenomenon are not well understood. READ MORE

  4. 4. Preclinical studies of roscovitine

    Author : Marina Vita; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Roscovitine; Metabolism; Pharmacokinetics; LC-MS; Cdk-inhibitor; Toxicity;

    Abstract : Cyclin-dependent kinases (Cdks) are key enzymes implicated in vital functions of the cell including regulation of the cell cycle, apoptosis, transcription and differentiation. Abnormal regulation of these molecules has been correlated to several diseases, such as cancer, viral infections, neural disorders and kidney inflammations. READ MORE

  5. 5. Oxygen Metabolism in Experimental Kidney Disease

    Author : Ebba Sivertsson; Fredrik Palm; Peter Hansell; Jenny Nyström; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Kidney; kidney oxygenation; mitochondria; proteinuria; uncoupling protein; adenosine nucleotide transporter; diabetes; hyperthyroidism; thyroid hormone; hypertension; angiotensin II; CDK; AST-120; rats; mice; Fysiologi; Physiology;

    Abstract : Tubulointerstitial hypoxia has been proposed a unifying mechanism behind the development of chronic kidney disease (CKD), regardless of primary diagnosis. Important factors that contribute to the development of hypoxia are reduced bioavailability of nitric oxide (NO), oxidative stress and mitochondria uncoupling. READ MORE