Search for dissertations about: "CDK"

Showing result 6 - 10 of 43 swedish dissertations containing the word CDK.

  2. 6. Cyclins on the move : a time and a place for cyclin A2 and cyclin B1 in the human cell cycle

    Author : Helena Silva Cascales; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The ultimate aim of the cell cycle is to create an identical daughter cell. Therefore, correct progression through the different phases of the cell cycle is crucial to ensure faithful cell division. READ MORE

  4. 7. Regulation of G2 phase and long-term consequences of DNA damage

    Author : Anna Won Middleton; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cell proliferation requires the accurate replication of DNA and equal segregation of replicated genes, important for maintaining the integrity of newly formed cells. At the centre of this process is a series of coordinated events termed ‘the cell cycle’, which ensures cell proliferation proceeds with high fidelity. READ MORE

  5. 8. Regulation of Immunoglobulin Isotype Switching and of the Germinal Center Response

    Author : Minghui He; Eva Severinson; Jayanta Chaudhuri; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Abstract : After stimulation, B cells can undergo two types of genetic alteration in their immunoglobulin (Ig) genes: somatic hypermutation and class switch recombination (CSR), both of which are initiated by activation-induced cytidine deaminase (AID).Although class switching requires cell proliferation, the mechanism is partly unknown. READ MORE

  6. 9. The cell cycle regulators p18Ink4c and p19Ink4d : in vivo studies of their roles in tumorigenesis and development

    Author : Lisa Nilsson; Olle Heby; Martine Roussel; Klas Wiman; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi;

    Abstract : Progression through the G1, S, G2 and M phases of the cell cycle is controlled by cyclin-dependent kinases (Cdks) and cyclins. These proteins form active Cdk:cyclin complexes that phosphorylate specific substrates. READ MORE

  7. 10. The ABC of the cell cycle : roles of the mammalian Cdc25 isoforms

    Author : Andreas Lundgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cell cycle progression is mediated by Cyclin dependent kinases (Cdks) in complex with Cyclins. The activity of the Cyclin-Cdk complexes is regulated through a variety of levels: expression and proteolysis of Cyclins, binding of inhibitors, phosphorylations and subcellular localization. READ MORE