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Showing result 1 - 5 of 25 swedish dissertations matching the above criteria.

  2. 1. FET proteins in cancer and development

    Author : Mattias K Andersson; Göteborgs universitet; []
    Keywords : FUS; EWS; TAF15; FUS-DDIT3; myxoid liposarcoma; NF-κB; NFKBIZ; FLT1; CDK2;

    Abstract : Chromosomal translocations leading to rearrangements of FET family genes (FUS, EWSR1 and TAF15) are found in numerous human cancers. These genetic alterations result in the formation of fusion oncogenes that express potent chimeric oncoproteins able to promote tumor development. READ MORE

  4. 2. Targeting MYC and CDK2 in cancer : impacts on senescence, apoptosis and immune modulation

    Author : Wesam Bazzar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer is a disease in which cells acquire the ability to divide uncontrollably and invade other tissues. An important component of this process is the activation of oncogenes and inactivation of tumor suppressor genes. READ MORE

  5. 3. Modulating the activity of the c-Myc oncoprotein : implications for therapeutic treatment

    Author : Per Hydbring; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The Myc oncoprotein regulates numerous cellular processes and is frequently deregulated in cancer due to genetic lesions. However, in addition to its tumor promoting activity, Myc and other oncoproteins induce intrinsic safe-guard mechanisms against tumorigenesis like apoptosis and cellular senescence, which have to be overcome by additional genetic lesions for cellular transformation. READ MORE

  6. 4. Signaling pathways in the development of female germ cells

    Author : Deepak Adhikari; Kui Liu; Elisabet Stener-Victorin; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ovary; primordial follicle; activation; mTORC₁; PI₃K; oocyte maturation; MPF; Cdk₁; medicinsk biokemi; Medical Biochemistry;

    Abstract : Primordial follicles are the first small follicles to appear in the mammalian ovary. Women are born with a fixed number of primordial follicles in the ovaries. Once formed, the pool of primordial follicles serves as a source of developing follicles and oocytes. READ MORE

  7. 5. Vascular development and safeguard mechanisms against tumorigenesis : oncogene-induced apoptosis and cellular senescence

    Author : Eduar Hejll; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis;

    Abstract : Angiogenesis, apoptosis and senescence are all cellular processes that have an impact on tumor development. Angiogenesis or the new vessel formation from pre-existing ones is known to be required for invasive tumor growth and metastasis. READ MORE