Search for dissertations about: "CDK2"

Showing result 11 - 15 of 25 swedish dissertations containing the word CDK2.

  2. 11. Antiproliferative action of estrogen receptor beta and Hes-1 in breast cancer

    Author : Johan Hartman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer is the most common malignancy among Swedish women. Although the mechanism behind the tumorigenesis remains unclear, estrogen receptor a (ERa) plays an important role in the progression of breast cancer and is regarded as a target for endocrine therapy. READ MORE

  4. 12. Cyclin E overexpression and associated events in human breast cancer

    Author : Maria Stighall; Malmö Patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; tumour growth pattern; invasion; proliferation; ID2; cyclin E; pRb; cell cycle; breast cancer;

    Abstract : Unrestrained proliferation is a hallmark of cancer and genetic defects within G1/S-phase regulation and the pRb pathway occur frequently. Proliferation control can be circumvented either by excess cyclin D1 or cyclin E, alterations that can define two alternative tumour biologic pathways in breast cancer. READ MORE

  5. 13. Role of integrin signaling in cell proliferation and survival

    Author : Wenjie Bao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Integrins function as transmembrane cell adhesion receptors for the surrounding extracellular matrix (ECM). Within the tissues, integrins attach the cells to the surrounding ECM and sense the ECM environment by triggering diverse arrays of signaling pathways that are essential for the control of many central cellular functions, including cell proliferation and survival. READ MORE

  6. 14. Interferon-alpha signaling and cell cycle regulation in neuroendocrine tumors of the digestive system

    Author : Yinghua Zhou; Uppsala universitet; []
    Keywords : Medical sciences; interferon-α; carcinoid tumors; interferon regulatory factor; p68; PKR; p21; p27; cell cycle; cyclin-dependent kinase; protein phosphorylation; protein trafficking; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : The prognosis for untreated carcinoid patients is poor and their quality of life is low. IFN-α treatment has shown a response rate of 50-80%, however, the antitumor mechanism has not been elucidated. READ MORE

  7. 15. Functional investigation of prognostic biomarkers and therapeutic targets in glioma brain tumors

    Author : Kaveh M Goudarzi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Gliomas are known to be the most prevalent primary tumors of the central nervous system, of which glioblastoma is the most aggressive type with a median survival less than 2 years and no available cure. Studies in this thesis investigated the significance of two potentially important proteins in glioma biology, the transcription factor PROX1 and the histone chaperone NPM1, and the interplay of the therapeutic targets p53 and mTOR. READ MORE