Search for dissertations about: "CDK2"

Showing result 6 - 10 of 25 swedish dissertations containing the word CDK2.

  2. 6. p57Kip2, a glucocorticoid-induced CDK inhibitor, involved in cell proliferation, apoptosis and differentiation

    Author : Magnus Samuelsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : p57Kip2 ; g lucocorticoids; cell cycle; apoptosis; lung development; transcriptional regulation;

    Abstract : Glucocorticoids (GCs), are steroid hormones with several important physiological implications, of which some are connected with the ability of GCs to inhibit cell proliferation. Although GC treatment normally accumulates cells in the GI phase of the cell cycle, the mechanisms behind this phenomenon are not well understood. READ MORE

  4. 7. MYC-driven Medulloblastoma : New Targeted Therapies and Mechanisms of Recurrence

    Author : Anna Borgenvik; Fredrik J. Swartling; Lars-Gunnar Larsson; Sonja Hutter; Pratiti (Mimi) Bandopadhayay; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Pediatric cancer; Recurrence; MYC; MYCN; SOX9; Treatment; Bet bromodomains; Cyclin-dependent kinases; Oncology; Onkologi; Medicinsk vetenskap; Medical Science;

    Abstract : Medulloblastoma is the most common malignant brain tumor of childhood. It arises in the posterior fossa but presents with distinct histological and molecular features. Hence, medulloblastoma is divided into four molecular subgroups, WNT, SHH, Group 3, and Group 4. READ MORE

  5. 8. The role of cyclin E in cell cycle regulation and genomic instability

    Author : Susanna Ekholm-Reed; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cyclin E; cell cycle; Restriction point; pre-RC; Mcm proteins; DNA replication; tumorigenesis; proteolysis; hCdc4;

    Abstract : Cyclin E, a positive regulatory subunit of Cdk2, normally accumulates periodically at the G1/S transition, where it promotes entry into S phase and other DNA replication-associated functions. However, in many types of human cancer, cyclin E is overexpressed and in some cases its expression becomes deregulated, a phenomenon generally associated with poor prognosis. READ MORE

  6. 9. Immunofluorescence studies on the cell cycle expression of cyclin A and cyclin E

    Author : Fredrik Erlandsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cell cycle regulation; cyclin A; cyclin E; immunofluorescence staining;

    Abstract : Cell cycle progression is tightly regulated in normal eucaryotic cells. Cancer is caused by the transformation of cells, and is always associated with defects in the cell cycle regulatory machinery. READ MORE

  7. 10. Interplay between the Myc oncoprotein, cyclin-dependent kinases and E3 ubiquitin ligases

    Author : Hamid Reza Sharifi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mammalian cells grow, divide, and die in a precise and orderly fashion. For cells to grow and maintain their integrity they need to communicate at both intracellular and extracellular level. READ MORE