Search for dissertations about: "CDKN2B"
Showing result 1 - 5 of 10 swedish dissertations containing the word CDKN2B.
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1. Dissecting Phenotypic Variation in Pigmentation using Forward and Reverse Genetics
Abstract : Coat color and patterning phenotypes have been extensively studied as a model for advancing our understanding of the relationship between genetic and phenotypic variation. In this thesis, genes of relevance for pigment cell biology were investigated. The dissertation is divided in two parts. READ MORE
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2. Molecular Genetic Studies of Sporadic and MEN1-Associated Endocrine Pancreatic Tumors
Abstract : Pancreatic endocrine tumors (PETs) may cause typical syndromes of hormone excess, or appear clinically non-functioning without hormonal symptoms. PETs occur sporadically, in association with the multiple endocrine neoplasia type 1 (MEN1) syndrome, or rarely the von Hippel-Lindau syndrome. READ MORE
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3. Role of the CDKN2A and related cell cycle regulatory genes in melanoma and other human cancers
Abstract : The main objective of this thesis has been to investigate the involvement of the CDKN2A (p16INK4a and p14ARF) and related cell cycle regulatory genes in melanoma and other types of human cancer. The CDKN2A gene represents a unique locus in the entire human genome. READ MORE
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4. Cell cycle regulatory genes in human astrocytic tumors
Abstract : Cancer is a genetic disorder of somatic cells. Neoplastic transformation and malignant progression may be a consequence of accumulated multiple genetic changes in a cell. Astrocytic gliomas are the commonest brain tumors in humans. READ MORE
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5. Prognostic and biological implications of epigenetic changes in leukemia
Abstract : The field of epigenetic research in hematology and oncology is rapidly expanding. Even so, reliable data linking epigenetic changes to clinical outcomes are scarce. We conducted two retrospective studies in AML. READ MORE