Search for dissertations about: "CFTR mRNA"

Found 5 swedish dissertations containing the words CFTR mRNA.

  2. 1. Advances in Pharmacological Treatment of Cystic Fibrosis

    Author : Igor Oliynyk; Godfried M. Roomans; Marie Johannesson; Hugo R. de Jonge; Örebro universitet; []
    Keywords : Cystic fibrosis; CFTR; chloride transport; N-acetylcysteine; NO-donors; duramycin; intracellular calcium; azithromycin; MEDICINE; MEDICIN; Medicin; Medicine;

    Abstract : Cystic fibrosis (CF) is an inborn, hereditary disease, due to mutations in the gene for a cAMP-activated chloride (Cl-) channel, the cystic fibrosis transmembrane conductance regulator (CFTR). As a result of impaired ion and water transport,the airway mucus is abnormally viscous, which leads to bacterial colonization. READ MORE

  4. 2. Cell responses in infected and cystic fibrosis respiratory epithelium

    Author : Rashida Hussain; Godfried M . Roomans; Maria Björkqvist; Ferenc Karpati; Hans Kollberg; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; airway epithelial cells; cystic fibrosis; bacterial infection; CFTR; ENaC; chloride transport; intracellular calcium; P. aeruginosa internalization; Biomedicin; Biomedicine;

    Abstract : Respiratory Epithelium. Örebro Studies in Medicine 99. Cystic fibrosis (CF) is caused by a mutation in a cAMP-activated chloride (Cl-) channel (CFTR). Mortality and morbidity in CF is mainly due to the deregulated responses of the airway epithelial cells. READ MORE

  5. 3. Aspects on puberty and fertility among females with cystic fibrosis a multidisciplinary study on humans and rats

    Author : Marie Johannesson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : cystic fibrosis; puberty; fertility; hormonal profiles; CFTR mRNA; MDR mRNA; rat brain; pregnant rat lung; psychosocial aspects.;

    Abstract : Due to intensified symptomatic treatment, a majority of patients with cystic fibrosis (CF) now go through puberty and reach adulthood. This provides new challenges for the CF health care providers. READ MORE

  6. 4. Studies on mechanisms in liver fibrosis

    Author : Nils Kinnman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : bile duct epithelial cell; chernotaxis; cholestasis; cystic fibrosis; cystic fibrosis transmembrane conductance regulator; endothelin; hepatic stellate cell; hepatitis C virus; liver fibrosis; platelet-derived growth factor; platelet-derived growth factor receptor [beta]; smooth muscle [alpha]-actin; transforming growth factor- [beta]; tumor necrosis factor-[alpha];

    Abstract : The aim of the present study was to elucidate mechanisms involved in liver fibrogenesis, the wound healing response of the liver to chronic injury. A role for TNF-[alpha] and all three isoforms of TGF-[beta] in the pathogenesis of hepatitis C related liver disease was suggested by the finding of increased expression of TGF-[beta]1-3, latent TGF-[beta] binding protein (LTBP), and TNF-[alpha] by immunohistochemistry in areas of inflammation and fibrosis in liver tissue from untreated patients with hepatitis C. READ MORE

  7. 5. Analytical approaches to the study of mucin glycosylation

    Author : Kristina A Thomsson; Göteborgs universitet; []
    Keywords : mucins; O-linked glycosylation; mass spectrometry; cystic fibrosis; salivary mucins; sulfated oligosaccharides.;

    Abstract : Mucins constitute the major protein component of the mucus layer, which covers the epithelial surfaces of the respiratory, the gastrointestinal and the genitourinary tracts. Mucins carry O-linked oligosaccharides which contribute to the molecule by 50-80 weight percent, and these can be highly diverse, with 50-150 different oligosaccharides found on a purified mucin population. READ MORE