Search for dissertations about: "CGRP"

Showing result 1 - 5 of 76 swedish dissertations containing the word CGRP.

  1. 1. Distribution of CGRP and CGRP receptor in the trigeminovascular system and CNS

    University dissertation from Medicine (Lund)

    Author : Sajedeh Eftekhari; Lunds universitet.; Lund University.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CGRP; CLR; RAMP1; migraine; trigeminovascular system; pain; cerebellum;

    Abstract : Calcitonin gene-related peptide (CGRP) has a key role in the pathophysiology of migraine and is associated with activation of the trigeminovascular system. Recently, CGRP receptor antagonists have been developed with clinical efficacy. READ MORE

  2. 2. Brain Stem Involvement in Immune and Aversive Challenge

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Jakob Paues; Linköpings universitet.; Linköpings universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipopolysaccharide; Lithium Chloride; anorexia; aversion; parabrachial; brain stem; melanocortin; CGRP; enkephalin; MEDICINE Physiology and pharmacology Physiology Neurobiology; MEDICIN Fysiologi och farmakologi Fysiologi Neurobiologi;

    Abstract : Activation of the immune system by e.g. bacteria induces the acute-phase-response and sickness behaviour. The latter encompasses among other things fever, lethargy, anorexia and hyperalgesia. READ MORE

  3. 3. A study on the vascular effects of prostaglandin F2α[ and latanaprost in the eye with special reference to the surface hyperaemia after topical administration

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Astin; Uppsala universitet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Prostaglandin F2a; Prostaglandin F2a-isopropyl ester; latanoprost; latanoprost acid; ocular hyperaemia; blood flow; sensory nerves; veins; arteries; nitric oxide; substance P; CGRP; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; Pharmacognosy; farmakognosi;

    Abstract : The ocular hypotensive effect of topically applied prostaglandins is usually accompanied byconjunctival hyperaemia and irritation. The purpose of the present study was to investigate thepharmacological mechanism of the ocular surface hyperaemia induced by topically appliedprostaglandins, particularly prostaglandin F2α (PGF2α) and its synthetic analogue latanoprost, aselective FP prostanoid receptor agonist. READ MORE

  4. 4. Physiology and Pharmacology of C-fibres in the rabbit eye

    University dissertation from Pharmacology, 223 62 Lund

    Author : Zunyi Wang; [1996]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; PPT-mRNA; NO; PACAP; CGRP; neurokinins; resiniferatoxin; capsaicin; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : C-fibre neuropeptides, such as tachykinins and calcitonin-gene related peptide (CGRP), play an important role in neurogenic inflammation. The present work deals with five different aspects of the physiology and pharmacology of C-fibres. READ MORE

  5. 5. Pituitary adenylate cyclase activating peptide: a neuropeptide in the sensory nervous system

    University dissertation from Pharmacology, 223 62 Lund

    Author : Yanzhen Zhang; [1996]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ hybridization; immunocytochemistry; peptide expression; inflammation; nerve injury; axotomy; capsaicin; pain; nociceptive; formalin test; C-fibres; sensory neurons; spinal cord; dorsal root ganglia; mRNA; neuropeptides; VIP; SP; PACAP; CGRP; Northern blot; rat; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : This thesis deals with the expression of pituitary adenylate cyclase activating peptide (PACAP) in sensory C-type cells and primary afferent fibres and its possible role in nociceptive transmission. PACAP-expression, -release, -synthesis and -function were investigated in a series of measurements using immunocytochemistry, radioimmunoassay, in situ hybridization histochemistry, Northern blot, electrophysiology, superficial spinal perfusion and nerve injury. READ MORE