Search for dissertations about: "CGRP"

Showing result 1 - 5 of 81 swedish dissertations containing the word CGRP.

  2. 1. Distribution of CGRP and CGRP receptor in the trigeminovascular system and CNS

    Author : Sajedeh Eftekhari; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CGRP; CLR; RAMP1; migraine; trigeminovascular system; pain; cerebellum;

    Abstract : Calcitonin gene-related peptide (CGRP) has a key role in the pathophysiology of migraine and is associated with activation of the trigeminovascular system. Recently, CGRP receptor antagonists have been developed with clinical efficacy. READ MORE

  4. 2. Brain Stem Involvement in Immune and Aversive Challenge

    Author : Jakob Paues; Anders Blomqvist; Finn Hallböök; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipopolysaccharide; Lithium Chloride; anorexia; aversion; parabrachial; brain stem; melanocortin; CGRP; enkephalin; Neurobiology; Neurobiologi;

    Abstract : Activation of the immune system by e.g. bacteria induces the acute-phase-response and sickness behaviour. The latter encompasses among other things fever, lethargy, anorexia and hyperalgesia. READ MORE

  5. 3. Peripheral Regulation of Pain and Itch

    Author : Elín Ingibjörg Magnúsdóttir; Malin C. Lagerström; George H. Caughey; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain; itch; CGRP; TRPV1; mast cell; mast cell protease; mMCP4; mMCP6; CPA3; endothelin-1; compound 48 80; MRGPRX2; single-stranded oligonucleotide;

    Abstract : Pain and itch are diverse sensory modalities, transmitted by the somatosensory nervous system. Stimuli such as heat, cold, mechanical pain and itch can be transmitted by different neuronal populations, which show considerable overlap with regards to sensory activation. READ MORE

  6. 4. Gut Feelings - From Brain to Gut and from Lumen to Gut

    Author : Xiaowen Cheng; Neurogastroenterologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Enteric nervous system; cerebral ischemia; galectine-3; tuft cell; CGRP; CCK; GLP-1; 5HT; PYY;

    Abstract : Part 1: From Brain to GutThe brain is an organ with a high energy requirement. To meet this demand, the brain needs a continuous and well-regulated blood supply. In situations where the brain, or parts of the brain, does not receive sufficient blood flow injury arise. READ MORE

  7. 5. Interactions between the brain and the immune system in pain and inflammation

    Author : Joanna Zajdel; David Engblom; Annika Thorsell; Jan Pieter Konsman; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; pain; EP3Rs; serotonin; CGRP; conditioned taste aversion; maternal separation; maternal buffering;

    Abstract : Reciprocal interactions between the nervous and immune systems have gained a lot of attention in the last two decades, especially after demonstrating that cytokine immunotherapies can induce depression and after describing the inflammatory reflex. A lot of effort has been dedicated to understanding how the signals from the immune system reach the brain and vice versa, and on their role in health and disease. READ MORE