Search for dissertations about: "CHS 828"

Showing result 6 - 10 of 11 swedish dissertations containing the words CHS 828.

2. 6. Application of In Vitro Chemosensitivity Testing for Evaluation of New Cytotoxic Drugs in Chronic Lymphocytic Leukaemia

   Author : Anna Åleskog; Jan Liliemark; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical drug development; chronic lymphocytic leukaemia; cytotoxicity; in vitro assay; cytotoxic drug development; CHS 828; IgVH mutation status; Klinisk läkemedelsutveckling; Pharmaceutical chemistry; Läkemedelskemi; Clinical Pharmacology; klinisk farmakologi;

   Abstract : Despite major advances in the understanding of the biology of chronic lymphocytic leukaemia (CLL), progress in improving its treatment has been limited and it still remains an incurable disorder. In the present research, we have performed in vitro drug sensitivity testing of primary CLL cells for preclinical evaluation of cytotoxic drugs, using the fluorometric microculture cytotoxicity assay (FMCA). READ MORE

4. 7. Application of new methodology for preclinical development of anticancer drugs : With special focus on camptothecin derivatives and the cyanoguanidine CHS 828

   Author : Elin Jonsson; Uppsala universitet; []
   Keywords : Medical sciences; drug development; hollow-fiber model; FMCA; human tumour cell; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

   Abstract : This work describes the development and evaluation of new methods for preclinical anticancer drug development. The methods were specifically applied to study camptothecin analogues and the new compound CHS 828 (N-(4-chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine) currently in early clinical trials. READ MORE

5. 8. Application of a New Logic to Old Drugs: Angiogenesis Inhibition in Neuroblastoma

   Author : Åsa Svensson; Rolf Christofferson; Per Kogner; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; angiogenesis; neuroblastoma; CHS 828; digoxin; combination treatment; Cellbiologi; Cell biology; Cellbiologi; Medical Cell Biology; medicinsk cellbiologi;

   Abstract : Neuroblastoma is one of the most common solid cancers of early childhood. In Sweden, approximately 10-15 cases occur annually. The overall five-year neuroblastoma survival in Europe is approximately 45%. Since cancer treatment involves drugs with risks of side effects in the growing child, there is a need for more effective and less toxic drugs. READ MORE

6. 9. Treatment of Experimental Neuroblastoma with Angiogenic Inhibitors

   Author : Ulrika Bäckman; Rolf Christofferson; Sven Påhlman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Angiogenesis; Neuroblastoma; MYCN; VEGF; SU11657; SU5416; TNP-470; zoledronic acid; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Abstract : Neuroblastoma is a childhood cancer that originates from neuroblasts in the peripheral nervous system. Neuroblastoma show considerable heterogeneity with respect to location, responsiveness to treatment and prognosis. READ MORE

7. 10. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres

   Author : Lena E Friberg; Mats Karlsson; Alan Boddy; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI; farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Abstract : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. READ MORE