Search for dissertations about: "CLL"

Showing result 11 - 15 of 105 swedish dissertations containing the word CLL.

  2. 11. Regulation of T-cell proliferation and B-CLL apoptosis by CD6 and FAS/FASL

    Author : Lydia Maria Osorio Fernández; Karolinska Institutet; Karolinska Institutet; []
    Keywords : T-cell activation; CD6; B-CLL; apoptosis; Fas; FasL;

    Abstract : T-cell activation involves the interaction between the T-cell receptor (TCR) and the peptide/MHC complex presented on an antigen-presenting cell. However, this is not sufficient for the full development of T cell responses and co-stimulatory signals from accessory molecules are required. READ MORE

  4. 12. Characteristics of EBV-infected B cell lines and B-CLL clones which determine their interaction with lymphocytes

    Author : Javier Federico Avila-Carino; Karolinska Institutet; Karolinska Institutet; []
    Keywords : EBV; Burkitt Iymphoma; CLL; MLC; antiviral response phenotype; cytokines.;

    Abstract : The results concerning T Iymphocyte mediated recognition of Epstein-Barr virus (EBV) carrying Burkitt Iymphoma (BL) cell lines and EBV-infected chronic Iymphocytic leukemia (CLL) B cells contribute to the understanding of the generally harmless host-EBV interaction and may be extrapolated to the fate of normal B cells after EBV infection. The phenotype of EBV negative BL lines resembles resting B cells. READ MORE

  5. 13. Restricted antigen recognition in B cell chronic lymphocytic leukemia

    Author : Anna Lanemo Myhrinder; Anders Rosén; Linköpings universitet; []
    Keywords : Chronic lymphocytic leukemia; auto antigens; CLL cell lines; MEDICINE; MEDICIN;

    Abstract : Chronic lymphocytic leukemia (CLL) cells are considered to be derived from antigen-exposed B cells. To further explore the antigen-driven selection behind the leukemogenesis of CLL, we performed immunoglobulin (Ig) specificity screening of 7 CLL cell lines and 23 primary CLL clones from patient peripheral blood. READ MORE

  6. 14. Importance of microenvironment and antigen in the regulation of growth and survival of CLL cells

    Author : Ann-Charlotte Bergh; Anders Rosén; Richard Rosenquist Brandell; Dimitar Efremov; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Chronic lymphocytic leukemia (CLL) cells rapidly die when put in culture implying that microenvironmental signals delivered by accessory cells confer CLL cells with a growth advantage. Recent findings show that CLL cells are antigen experienced and antigen binding play a critical role in the pathogenesis of the disease. READ MORE

  7. 15. Targets for immune mediated killing of tumor cells and T cell functions in B-CLL

    Author : Eva D Rossmann; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Chronic lymphocytic leukemia; apoptosis; monoclonal antibody therapy; quantitative flow cytometry; cytokines; T cell dysfunctions;

    Abstract : There is a great need for developing and improving treatment alternatives in B-cell chronic lymphocytic leukemia (B-CLL). New therapeutical approaches based on the manipulation of the immune system enable establishment of enhanced control over the malignant clone. READ MORE