Search for dissertations about: "CLL"

Showing result 16 - 20 of 105 swedish dissertations containing the word CLL.

  2. 16. Natural specific T cell immunity in patients with B-cell chronic lymphocytic leukaemia (B-CLL) : (A clinical and immunological study)

    Author : Mohammad Reza Rezvany; Karolinska Institutet; Karolinska Institutet; []
    Keywords : B-CLL; TCR usage; clonality; natural T cell immunity; costimulatory molecules; dendritic cells; cytokines; tumor derived VH-CDR3.;

    Abstract : Analysis of TCRBV (T-cell receptor B variable) gene usage of the T cell repertoire in patients with B cell chronic lymphocytic leukaemia (B-CLL) and age-matched healthy control donors showed that major perturbations were more frequently seen in the CD4+ T cell subset than in CD8 population. Analysis of the CDR3 length polymorphism revealed a significantly higher degree of clonality within the CD4+ and CD8+ T cell repertoire of patients as compared to the normal control population. READ MORE

  4. 17. T cells in patients with B-cell chronic lymphocytic leukemia (B-CLL) and multiple myeloma (MM) : an immunological study

    Author : Shahryar Kiaii; Karolinska Institutet; Karolinska Institutet; []
    Keywords : T cell; B-cell Chronic Lymphocytic Leukemia ; Multiple Myeloma ; signaling; gene expression;

    Abstract : There are several lines of evidence that T cells in patients with Multiple Myeloma (MM) and B-cell Chronic Lymphocytic Leukemia (B-CLL) are phenotypically aberrant. The overall aim of this thesis was to study T cells with a focus on TCR-signaling pathways in these two B-cell malignancies. The role of T-cells in B-CLL etiology was also examined. READ MORE

  5. 18. Molecular characterization of apoptosis in B-cell chronic lymphocytic leukemia

    Author : Anna Olsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : B-CLL; apoptosis; TRAIL; FLIP; Bmf; Bfl-1;

    Abstract : B-cell chronic lymphocytic leukemia (B-CLL), characterized by an accumulation of monclonal B cells, is the most common adult leukemia in the Western world. Defective apoptosis is considered to contribute to cell accumulation, disease progression and resistance to therapy in BCLL. READ MORE

  6. 19. p53 guardian of the genome and target for improved treatment of leukemia

    Author : Hareth Nahi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : p53; p14ARF; PRIMA; RITA; AML; CLL; HDM-2;

    Abstract : P53 acts in several cellular processes as cell cycle checkpoints, DNA repair senescence and the surveillance of genomic integrity. Wt p53 inhibits cancer processes by causing cell cycle arrest and apoptosis. P53 is strongly regulated by the HDM-2 protein, which builds a complex with p53 leading to proteosomal degradation of p53. READ MORE

  7. 20. Genetic changes in lymphoid leukemia

    Author : Marianne Hammarsund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CLL; HCL; genetic aberrations; 13q14; chromosome 5; antisense; bicistronic;

    Abstract : It is today generally accepted that the vast majority of malignant tumors arise as a result of genetic changes in critical genes involved in the tightly regulated control of cell growth and cell death. Despite the remarkable progress in the identification of such genes during the past two decades, many cancer genes probably remain to be identified. READ MORE