Search for dissertations about: "CLint"

Found 4 swedish dissertations containing the word CLint.

  2. 1. Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

    Author : Erik Sjögren; Hans Lennernäs; Scott Obach; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatic disposition; pharmacokinetics; mechanistic modelling; drug-drug interactions; enzyme kinetics; Vmax; Km; CLint; carrier-mediated transport; active transport; modelling; in vitro-in vivo extrapolation; physiologically based pharmacokinetic model; optimal experimental design; experimental optimization; data analysis optimization; PHARMACY; FARMACI; Biopharmacy; Biofarmaci; Biopharmaceutics; Biofarmaci;

    Abstract : The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. READ MORE

  4. 2. Metabolism of quinoline 3-carboxamide compounds, a group of synthetic immunomodulators, in various species

    Author : Helen Tuvesson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymologi; Proteiner; enzymology; Proteins; Gastroenterologi; Gastro-enterology; pharmacokinetics; enzyme kinetics; quinoline 3-carboxamides; Keywords: Metabolism; cytochrome P450;

    Abstract : Cytochrome P450 (CYP) is involved in the metabolism of the majority of clinically used drugs. We have studied the CYP mediated metabolism of quinoline 3-carboxamides, a group of synthetic immunomodulators in liver microsomal preparations from various species. READ MORE

  5. 3. True and False Intentions: A Mental Representational Approach

    Author : Sofia Calderon; Göteborgs universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; deception; true and false intentions; construal level theory; mental representation; abstraction; action identification theory;

    Abstract : The study of true and false intentions is a specific case of deception-detection research. The focus is on how to discriminate between lies and truths about future behavior, as opposed to previous deception research that focused almost exclusively on past behavior. READ MORE

  6. 4. Genetic and metabolic studies towards personalized conditioning regimen prior to stem cell transplantation

    Author : Ibrahim El-Serafi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and non- malignant diseases. The busulphan (Bu)/cyclophosphamide (Cy) combination is one of the most common conditioning regimens given prior to HSCT. READ MORE