Search for dissertations about: "CML"

Showing result 1 - 5 of 53 swedish dissertations containing the word CML.

  2. 1. Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate

    Author : Yuan Wei; Göteborgs universitet; []
    Keywords : CML; imatinib; BCR-ABL; apoptosis; mutation; T-lymphocyte;

    Abstract : The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML). Imatinib mesylate (imatinib, Glivec® or Gleevec®), a small molecule inhibitor of the BCR-ABL tyrosine kinase, is now the first-line treatment for all newly diagnosed chronic phase CML patients. READ MORE

  4. 2. Targeting NOX2 in cancer

    Author : Ebru Aydin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; reactive oxygen species; immunotherapy; nox2; nk cells; melanoma; histamine; metastasis; leukemia; aml; cml; kras; mpd;

    Abstract : Reactive oxygen species (ROS) are short-lived, toxic derivatives of oxygen that are produced during mitochondrial respiration and by NADPH oxidases (NOX). By enzymatically generating ROS, the myeloid cell NOX2 plays a critical role in defense against bacteria and other microorganisms. READ MORE

  5. 3. Tumor-targeted superantigens for experimental immunotherapy of human leukemia/lymphoma

    Author : Cecilia Weigelt; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; SAg; SEA; SEAm; HLA class II; TCR; CFL; SDCC; cytotoxicity; TNF a; IFN g; mAb; PA-SEAm; anti-CD19-Fab-SEAm; B-CLL; B-NHL; AML; CML; immunotherapy; Onkologi; Oncology; Onkologi; Clinical Immunology; klinisk immunologi;

    Abstract : Bacterial superantigens (SAgs) have the property of stimulating high proportions of T cells expressing certain TCR Vβ sequences. The SAg first binds with high affinity to HLA class II molecules on the target cell and then stimulates the T cell to produce cytokines and to become cytotoxic. READ MORE

  6. 4. Modelling animal populations

    Author : Åke Brännström; Umeå universitet; []
    Keywords : population model; stochastic population model; population dynamics; discrete time model; Beverton-Holt model; Skellam model; Hassell model; Ricker model; first principles; coupled map lattice; CML; area integral; square function; Mathematics; matematik;

    Abstract : This thesis consists of four papers, three papers about modelling animal populations and one paper about an area integral estimate for solutions of partial differential equations on non-smooth domains. The papers are: I. Å. Brännström, Single species population models from first principles. READ MORE

  7. 5. Cell Surface Markers as Therapeutic Targets in Myeloid Leukemia

    Author : Niklas Landberg; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CML; AML; Cell surface markers; Leukemic stem cells; Myeloid leukemia; Antibody-based targeting; CML; AML; Cell surface markers; Leukemic stem cells; Myeloid leukemia; Antibody-based targeting;

    Abstract : .... READ MORE