Search for dissertations about: "CNI-1493"

Showing result 1 - 5 of 6 swedish dissertations containing the word CNI-1493.

  2. 1. Cytokines and cytokine-directed intervention in experimental arthritis

    Author : Karin Palmblad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : pro-inflammatory cytokines; collagen-induced arthritis; CNI-1493; HMG-1;

    Abstract : Rheumatoid arthritis (RA) is a common chronic autoimmune and inflammatory disease. Although the etiology of RA remains unknown, a general understanding of the pathogenesis is steadily increasing. The macrophage products tumor necrosis factor (TNF) and interleukin 1 (IL-1) are recognized as pivotal mediators in the arthritic process. READ MORE

  4. 2. Modulation of the inflammatory response in experimental bacterial meningitis

    Author : Carl Granert; Karolinska Institutet; Karolinska Institutet; []
    Keywords : bacteria; meningitis; adhesion; leukocytes; microcirculation; fucoidin; cytokines; tumor necrosis factor; interleukin; CNI-1493; macrophage; CNS; inflammation; experimental;

    Abstract : In bacterial meningitis, tissue damage in the central nervous system (CNS) is inflicted by the host's inflammatory response to invading pathogens, rather than by the bacteria itself. Adjuvant treatment with anti-inflammatory drugs in experimental bacterial meningitis has demonstrated beneficial effects on CNS pathology. READ MORE

  5. 3. Modulation of inflammatory mediators during experimental bacterial meningitis

    Author : Hana Khidir Abdalla; Kristian Riesbeck; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Bacterial meningitis is a worldwide health problem with high morbidity and mortality mainly caused by Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae. It is an inflammatory disease of the central nervous system (eNS) initiated by cell wall or membrane components from the bacteria. READ MORE

  6. 4. Tissue destruction in arthritis : experimental studies

    Author : Esbjörn Larsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Destruction of joint cartilage and bone is one of the most serious consequences of chronic arthritis. Clinically, the standard assessment of joint destruction is performed by radiography. READ MORE

  7. 5. Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine

    Author : Gail E Mullins; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HMGB1; endothelial cells; pro-inflammatory; cytokine; RAGE;

    Abstract : High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as a late mediator of septic shock in mice. READ MORE