Search for dissertations about: "CNS compartments"

Showing result 1 - 5 of 9 swedish dissertations containing the words CNS compartments.

  2. 1. Studies of the Biology of Intrathecal Treatment in Progressive MS

    Author : Joakim Bergman; Anders Svenningsson; A. Tommy Bergenheim; Jonathan D. Gilthorpe; Joachim Burman; Magnus Andersson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Progressive Multiple Sclerosis; intrathecal treatment; Ommaya reservoir; anti-CD20 therapy; microdialysis; cerebrospinal fluid; CNS compartments; Progressiv Multipel Skleros; intratekal behandling; Ommaya reservoar; anti-CD20 terapi; mikrodialys; ryggmärgsvätska; sektioner i centrala nervsystemet; Neurology; neurologi;

    Abstract : Background: Multiple Sclerosis (MS) is a chronic, inflammatory, autoimmune disease, affecting the central nervous system (CNS). About 85% of afflicted present with a relapsing-remitting form of the disease (RRMS), for which a breakthrough in treatment was made in 2008 with rituximab, an antibody directed towards CD20, a surface antigen on B-cells. READ MORE

  4. 2. Studies of presenilin function in neurodegeneration and in human embryonic CNS during development

    Author : Beata Kostyszyn; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Presenilin-1 (PS1) and -2 (PS2) gene mutations cause early onset familial Alzheimer's disease (FAD). Presenilins provide gamma-secretase activity for cleaving transmembrane proteins such as the amyloid precursor protein (APP), Notch receptors and ligands. READ MORE

  5. 3. Immunopathogenesis of multiple sclerosis : big roles for small RNAs

    Author : Eliane Piket; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) and the leading cause of neurological disability in young adults. The exact cause of MS remains elusive despite enormous progress during the last decades in establishing the role of genetic and environmental risk factors. READ MORE

  6. 4. Neuroimmune mechanisms in chronic inflammation : translational studies of the inflammatory reflex

    Author : Johanna Estelius; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A functional immune system is crucial for our survival from the pathogens and toxins we are constantly subjected to. For reasons only partially understood, in some individuals the immune response instead target self antigens, as suggested in rheumatoid arthritis (RA), or environmental non-pathogenic antigens, as suggested in allergy, leading to a failure of resolution and development of a state of chronic inflammation. READ MORE

  7. 5. Control of early development of the lens and the retina

    Author : Tanushree Pandit; Lena Gunhaga; Paola Bovolenta; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lens; retina; BMP; FGF; chick; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : The nervous system is composed of two separate compartments, the central and the peripheral nervous system. The peripheral nervous system (PNS) composed mainly of sensory organs transmits sensory information to the central nervous system (CNS) comprising the brain and the spinal cord. READ MORE