Search for dissertations about: "COMBImageDL"

Found 1 swedish dissertation containing the word COMBImageDL.

2. 1. Algorithmic discovery, development and personalized selection of higher-order drug cocktails : A label-free live-cell imaging & secretomics approach

   Author : Efthymia Chantzi; Mats G Gustafsson; Ulf Hammerling; Andreas Bender; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug combination discovery and development; personalized pharmacotherapy; higher-order drug combination analysis; quantitative label-free live-cell imaging; secretomics; cell-cell communication; deep learning; convolutional neural networks; data mining; MapReduce; resampling; generalized highest single agent; COMBImageDL; COMBSecretomics; Bioinformatics; Bioinformatik; Pharmacology; Farmakologi; Engineering Science; Teknisk fysik;

   Abstract : An upward trend in clinical pharmacology is the use of multiple drugs to combat complex and co-occurring diseases due to better efficacy, decreased toxicity and reduced risk of evolving resistance. Despite high late-stage attrition rates and the need for multi drug treatments, most drug discovery and development efforts are still mainly focused on new one-size-fits-all monotherapies. READ MORE