Search for dissertations about: "COX-2"

Showing result 16 - 20 of 116 swedish dissertations containing the word COX-2.

  2. 16. Biomarkers for colon cancer : applications in human and rat studies

    Author : Pernilla C. Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Colon cancer biomarkers; faecal water; polyethylene glycol; synbiotics; COX-2 inhibitors;

    Abstract : Colon cancer is one of the major causes of cancer in industrialized countries, and it is caused by a combination of hereditary, environmental and dietary factors and lack of physical activity. Of these factors, diet is one of the most important. READ MORE

  4. 17. Dietary and genetic factors in the etiology of prostate cancer

    Author : Maria Hedelin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Epidemiology; prostate cancer; phytoestrogens; marine fatty acids; alcohol; polymorphism; SNP; estrogen receptor-beta; COX-2; gene-environmental interaction;

    Abstract : The etiology of prostate cancer is poorly understood. However, genetic factors may be more important than for many other malignancies. In addition, several studies suggest that dietary factors axe of etiologic importance. In particular, dietary intake of phytoestrogens or marine fatty adds from fish may protect against prostate cancer development. READ MORE

  5. 18. Vulvar vestibulitis syndrome : pathophysiology of the vestibular mucosa

    Author : Nina Bohm-Starke; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Vulvar vestibulitis syndrome; immunohistochemistry; QST; COX 2; NOS; laser Doppler perfusion imaging; intraepithelial nerve fibres; pain thresholds; sensory stimulation.;

    Abstract : Objective: The main purpose of the study was to survey possible pathophysiological changes of the vestibular mucosa in women with vulvar vestibulitis syndrome with regard to the clinical findings of superficial dyspareunia and mucosal erythema. Methods: Biopsies analysed with immunohistochemistry were used to study the morphology, distribution and neuropeptide content of the peripheral nerves, and the microvascularisation of the vestibular mucosa. READ MORE

  6. 19. Bioassay Development for Identification of Cyclooxygenase-2 Inhibitors of Natural Origin

    Author : Therese Ringbom; Angelika Vollmar; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; Farmakognosi; Pharmacognosy; Farmakognosi; Pharmacognosy; farmakognosi;

    Abstract : To examine cyclooxygenase-2 (COX-2) inhibitory effects of natural compounds and structurally related compounds, a radiochemical assay for measuring inhibition of COX-2 and COX-1 catalysed prostaglandin biosynthesis was optimised. That process resulted in the development of a reliable assay for finding COX-2 inhibitors in plants, and for investigating plant constituents pertaining to the inhibition of COX-2 and COX-1. READ MORE

  7. 20. Studies on the Effects of Plant and Food Constituents on Cyclooxygenase-2 : Aspects in Inflammation and Cancer

    Author : Ulrika Huss; Pia Wuorela; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; Farmakognosi; Pharmacognosy; Farmakognosi;

    Abstract : In inflammatory events, the cyclooxygenase-2 enzyme (COX-2) catalyses prostaglandin biosynthesis. This is a process, which could possibly be affected by natural compounds including those abundant in food. Two systems have been established to enable investigations of the effects of natural compounds on COX-2. READ MORE