Search for dissertations about: "COX-2"

Showing result 21 - 25 of 116 swedish dissertations containing the word COX-2.

  2. 21. The Role of Cyclooxygenase-2 in Models of Epilepsy and Traumatic Brain Injury : Effects of Selective Cyclooxygenase-2 Inhibitors

    Author : Tina Kunz; Tadeusz Wieloch; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Controlled cortical contusion injury; fluid percussion injury; limbic seizures; nuclear factor-kappa B; prostaglandin metabolism; TUNEL staining; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : Cyclooxygenase-2 (COX-2) catalyses prostaglandin synthesis from arachidonic acid during inflammation. COX-2 is expressed in the normal brain and is induced in neurological disorders. There is evidence that COX-2 is involved in secondary events leading to cell death in the brain. READ MORE

  4. 22. INFLAMMATION AND PROSTATIC CARCINOGENESIS ? A MORPHOLOGICAL STUDY OF THE HUMAN PROSTATE

    Author : Wanzhong Wang; Göteborgs universitet; []
    Keywords : prostate; carcinogenesis; chronic inflammation; atrophy; morphology; immunohistochemistry;

    Abstract : ABSTRACT: Chronic inflammation has been suggested to be linked to cancers. Inflammatory infiltrates are often found in and around foci of prostatic atrophy. These foci, called proliferative inflammatory atrophy (PIA), are proposed as precursors of prostate cancer (PCa) or prostatic intraepithelial neoplasia (PIN). READ MORE

  5. 23. Studies on expression and regulation of phospholipase A2 and cyclooxygenase 2 in gastrointestinal tissues with special reference to colorectal cancer

    Author : Jan Dimberg; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The phospholipases A2 (PLA2s) are phospholipid hydrolyzing enzymes that in mammalian cells exist in several different isoform including cytosolic PLA2 (cPLA2), group I PLA2 (PLA2-I) and group II PLA2 (PLA2-ll). PLA2 is involved in production of inflammatory mediators, membrane remodelling, digestive functions and stimulation of prolifemtion. READ MORE

  6. 24. Prostanoids and colorectal cancer

    Author : Annika Gustafsson Asting; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer prostanoid receptors cyclooxygenase PGE2 transcription factors;

    Abstract : Tumor disease is a main cause of death in Western countries and a most common malignancy is colorectal cancer (CRC). Growing tumors are dependent on interactions among several different cells as well as signaling pathways. READ MORE

  7. 25. Regulation of prostaglandin E2 synthesis in human gingival fibroblasts

    Author : Tülay Yucel-Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : prostaglandin E2; cyclooxygenase; phospholipase A2 interleukin-1; tumor necrosis factor [alpha]; epidermal growth factor; protein kinase C; tyrosine kinases; human gingival fibroblasts;

    Abstract : Prostaglandins, especially, prostaglandin E2 (PGE2) play an important role in inflammatory diseases such as rheumatoid arthritis and periodontitis. The aim of the present thesis was to study the production and the regulation of PGE2 with special reference to the key enzymes phospholipase A2 (PLA2) and cyclooxygenase (COX) at the rnRNA level in human gingival fibroblasts. READ MORE