Search for dissertations about: "COX-2"

Showing result 6 - 10 of 116 swedish dissertations containing the word COX-2.

  2. 6. An integrative strategy for targeted evaluation of biomarker expression in non-small cell lung cancer

    Author : Johanna Mattsson; Patrick Micke; Johan Botling; Fredrik Pontén; Åslaug Helland; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-small cell lung cancer; prognostic biomarkers; predictive biomarkers; immunohistochemistry; gene expression; COX-2; claudin; ALK; Medicinsk vetenskap; Medical Science;

    Abstract : Despite improvements in therapy, the prognosis for non-small cell lung cancer (NSCLC) patients remains poor, and cure is only possible in localized tumors after surgical resection. A new generation of targeted cancer drugs has led to the expectation that lung cancer therapy can be significantly improved, but these drugs are today only an option in a small subset of NSCLC patients, and their effect is temporary. READ MORE

  4. 7. p63 and potential p63 targets in squamous cell carcinoma of the head and neck

    Author : Linda Boldrup; Karin Nylander; Wendy Weinberg; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SCCHN; p63; Cox-2; EGFR; β-catenin; PP2A; p53; Tumour biology; Tumörbiologi;

    Abstract : Squamous cell carcinoma of the head and neck (SCCHN), the 6th most common cancer worldwide, has a low 5-year survival. Disease as well as treatment often causes patients severe functional and aesthetic problems. READ MORE

  5. 8. Involvement of Eicosanoid Signaling in Intestinal Epithelial Cell Survival

    Author : John Öhd; Malmö Experimentell patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; Tcf Lef; Bcl-2 family; b-catenin; 5-LO; apoptosis; cell survival; colorectal cancer; COX-2; LTD4; CysLT1 R; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Abstract : Eicosanoids are known to be involved in many different aspects of eukaryotic physiology and pathology. Notably, over the past 10 years much attention has been given to cyclooxygenase-2 (COX-2) due to its involvement in colorectal cancer. Less is known about the other major branch of arachidonic acid metabolism, namely the lipoxygenases (LO). READ MORE

  6. 9. Prostaglandin E2 in Brain-mediated Illness Responses

    Author : Louise Elander; Anders Blomqvist; Marianne Schultzberg; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostaglandin e2; PGE2; cox-1; cox-2; mPGES-1; fever; anorexia; food intake; HPA-axis; EP-receptor; LPS; IL-1; IL-6; MEDICINE; MEDICIN; Neurobiology; Neurobiologi;

    Abstract : We are unceasingly exposed to potentially harmful microorganisms. The battle against threatening infectious agents includes activation of both the innate and of the adaptive immune systems. READ MORE

  7. 10. Kinins : important regulators in inflammation induced bone resorption

    Author : Anna Bernhold Brechter; Ulf Lerner; Hans-Erik Claesson; Umeå universitet; []
    Keywords : Bone resorption; Osteoblasts; Kinins; B1 and B2 receptors; IL-1β; TNF-α; Prostaglandin; COX-2; RANKL; Transcription factors; IL-4; IL-13; Medical Cell Biology; medicinsk cellbiologi;

    Abstract : Inflammatory processes in, or in close vicinity of, the skeleton often lead to loss of bone tissue. Different cytokines have been shown to be involved as stimulators of inflammatory induced osteoclastic bone resorption. READ MORE