Search for dissertations about: "COX-inhibition"

Found 5 swedish dissertations containing the word COX-inhibition.

  2. 1. Regional pulmonary vasoreactivity, with special reference to nitric oxide, prostacyclin and body posture

    Author : Danguolé Rimeika; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Regional pulmonary perfusion; nitric oxide; prostacyclin; NOS-inhibition; COX-inhibition; shunt; one-lung ventilation;

    Abstract : The primary aim of the study was to investigate possible mechanisms behind the improved arterial oxygenation in ventilator-treated patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) when turned into prone position. A secondary aim was to discover new knowledge of possible importance for treatment of patients with oxygenation problems in intensive care and during anesthesia. READ MORE

  4. 2. Prostaglandins and angiogenesis in experimental cancer

    Author : Hans Axelsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; dorsal skin fold chamber; prostanoids; PGE2; indomethacin;

    Abstract : Background and aim. Genes, proteins and pathways have been identified and suggested as potential targets in tumor angiogenesis, but current anti-angiogenic therapies have provided only modest benefits in survival of cancer patients. READ MORE

  5. 3. Experimental studies of lipid mediator modulation of airway responsiveness

    Author : Willem Abma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Lipid mediators play an important role in responsiveness of the airways. The roles of prostanoids and leukotrienes in inducing airway inflammation and contraction are reasonably well established. READ MORE

  6. 4. Prostanoids and colorectal cancer

    Author : Annika Gustafsson Asting; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer prostanoid receptors cyclooxygenase PGE2 transcription factors;

    Abstract : Tumor disease is a main cause of death in Western countries and a most common malignancy is colorectal cancer (CRC). Growing tumors are dependent on interactions among several different cells as well as signaling pathways. READ MORE

  7. 5. Clinical studies on the role of eicosanoids in the asthmatic airway inflammation

    Author : Kameran Daham; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The underlying mechanisms in the asthmatic airway inflammation involve the interaction between different cells and mediators that consequently result in different clinical phenotypes. The aim of this thesis was to investigate the impact of inflammatory mediators, with emphasis on eicosanoids, on the inflammatory and functional airway responses under basal and triggered conditions in subjects with asthma, in particular ASA/NSAID-intolerant and allergic phenotypes. READ MORE