Search for dissertations about: "CPP"

Showing result 11 - 15 of 66 swedish dissertations containing the word CPP.

  2. 11. Cell-Penetrating Penetratin Peptides - Mechanistic Studies on Uptake Pathways and DNA Delivery Efficiency

    Author : Helene Åmand; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plasma membrane vesicle; Lysine; Stimulated endocytosis; Gene delivery; Cell surface affinity; Penetratin; Cell-penetrating peptide; Cysteine; Uptake; Arginine;

    Abstract : Delivery of gene-targeted drugs is limited by the inherently poor capacity of nucleic acids to overcome the membrane barrier of the cell, and development of vectors that can promote uptake is therefore crucial. Cell penetrating peptides (CPPs) have emerged as promising vector candidates due to their ability to deliver a wide range of macromolecular cargos into cells. READ MORE

  4. 12. Brain Tissue Oxygenation in Traumatic Brain Injury : Experimental and Clinical Studies

    Author : Karlis Purins; Anders Lewén; Per Enblad; Oliver Sakowitz; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain tissue oxygenation; Cerebral metabolism; Traumatic brain injury; Cerebral ischemia; Threshold levels; Neurovent-PTO; Microdialysis; Neurosurgery; Neurokirurgi;

    Abstract : Traumatic brain injury (TBI) is a major cause of death and disability. TBI is frequently followed by cerebral ischemia which is a great contributor to secondary brain damage. The main causes of cerebral ischemia are pathophysiological changes in cerebral blood flow and metabolism. READ MORE

  5. 13. Traumatic brain injury in elderly patients

    Author : Samuel Lenell; Per Enblad; Anders Lewén; Alfonso Lagares; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; Elderly; Outcome; Standardized neurosurgical intensive care; Quality register; Prognostic factors; Secondary insults; Neurointensive care monitoring; Pressure reactivity index; Optimal cerebral perfusion pressure; Cerebral autoregulation; Neurokirurgi; Neurosurgery;

    Abstract : The increase of elderly traumatic brain injury (TBI) patients constitutes a considerable challenge. The aim was therefore to specifically study elderly TBI patients with respect to patient characteristics, neurointensive care (NIC) and outcome, and to identify age specific features, which may be important for selection of patients and optimization of NIC in the elderly. READ MORE

  6. 14. Cerebral Perfusion during Cardiopulmonary Bypass

    Author : Thomas Tovedal; Fredrik Lennmyr; Stefan Thelin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Impaired superior vena cava (SVC) cannula outflow during cardiopulmonary bypass (CPB) is a frequent issue, often manifested by only marginal changes in routine monitoring parameters. Nevertheless, significant impact on cerebral perfusion may result. READ MORE

  7. 15. Secondary Insults in Neurointensive Care of Patients with Traumatic Brain Injury

    Author : Kristin Elf; Per Enblad; Pelle Nilsson; Elisabeth Ronne-Engström; Bertil Romner; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Traumatic brain injury; Neurointensive care; Monitoring; Secondary insults; Intracranial pressure; Cerebral perfusion pressure; Pressure reactivity; Temperature; Neural network; Outcome; Neurovetenskap; Neurology; Neurologi;

    Abstract : Traumatic brain injury (TBI) is a major cause of death and disability. Intracranial secondary insults (e.g. intracranial haematoma, brain oedema) and systemic secondary insults (e. READ MORE