Search for dissertations about: "CRBP"

Showing result 1 - 5 of 6 swedish dissertations containing the word CRBP.

  2. 1. Retinoids and vitamin D in skin and parathyroid glands

    Author : Liu Wei; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; all-trans retinoic acid 9-cis retinoic acid vitamin A. vitamin D. CRBP. CRABP. RAR. RXR. parathyroid hormone. calcium receptor; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : Vitamin D3 (VitD3) and retinoids are important factors involved in differentiation and proliferation in many cell systems. Their effects in skin, where retinoids and vitamin D are known to be crucially involved in keratinocyte differentiation and function,, and in the parathyroid, the overall regulatory organ in calcium homeostasis were studied. READ MORE

  4. 2. On retinoid receptors, Nurr1 and related transcription factors in the CNS

    Author : Rolf H Zetterström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Nurr1; NGFI-B; Nor1; RAR; RXR; CRBP; CRABP; substantia nigra; basal ganglia; dopamine; orphan receptor; vitamin A; retinoic acid; transcription factor;

    Abstract : It has long been known that retinoids (vitamin A derivatives) are required for normal development and growth; in excess however metabolites such as all-trans retinoic acid are potent teratogens. Retinoids exert their effects through transcription factors known as the retinoic acid receptors (RARam -ß and -y) and retinoid X receptors (RXRa, -ß and -y). READ MORE

  5. 3. Disruption of vitamin A metabolism by dioxin

    Author : Pi Högberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : TCDD; dioxin; vitamin A; retinoic acid; cellular retinol-binding protein; bone;

    Abstract : Vitamin A (retinoids) is a nutrient that plays a central role in development and remains essential for cell growth and differentiation throughout life. Dioxins are polychlorinated organic pollutants known to negatively affect the storage and body clearance of retinoids. READ MORE

  6. 4. Constitutive and TCDD-induced expression of Ah receptor responsive genes with special focus on the brain and pituitary

    Author : Ping Huang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) and related substances are ubiquitous environmental pollutants causing a number of pathological alterations, the most severe being progressive anorexia and body weight loss. The effects on body weight homeostasis suggest a possible involvement of the nervous system and neuroendocrine areas including the pituitary gland. READ MORE

  7. 5. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts vitamin A homeostasis in rodents : quantitative and mechanistic studies to support risk assessment

    Author : Nick Fletcher; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure is well-known to disrupt Vitamin A (retinoid) homeostasis in rats, resulting in decreased hepatic storage, as well as increased metabolism and excretion of retinoids. The aims of this thesis were (1) to clarify the species and strain sensitivity of TCDDinduced retinoid disruption and (2) to identify cellular targets of TCDD-induced retinoid disruption. READ MORE