Search for dissertations about: "CRISPR"

Showing result 16 - 20 of 101 swedish dissertations containing the word CRISPR.

  2. 16. Genetic predisposition for Multiple Myeloma. Identification and functional characterization of risk variants

    Author : Laura Duran Lozano; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; multiple myeloma; CRISPR Cas9; cancer genetics; functional characterization; Germline variants;

    Abstract : Multiple myeloma (MM) is a blood malignancy originating from plasma cells. First-degree relatives of patients with MM have two- to four-fold higher risk of MM. However, the molecular basis remains largely unknown. This Ph. READ MORE

  4. 17. Targeted Long-read Sequencing : Development and Applications in Medical Genetics

    Author : Ida Höijer; Ulf B. Gyllensten; Adam Ameur; Lars Feuk; Winston Timp; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; long-read sequencing; targeted sequencing; targeted enrichment; CRISPR-Cas9; off-targets; medical genetics; repeat expansion; structural variant;

    Abstract : Targeted sequencing has the advantage of providing pinpointed DNA information, while costs and data-analysis efforts are reduced. If targeted sequencing is combined with single molecule long-read sequencing, it can become a powerful tool to investigate genomic regions traditionally difficult using the predominantly used short-read sequencing platforms, including repetitive regions and large structural variants. READ MORE

  5. 18. The role of Nkx3.2 and Gdf5 during zebrafish skeletal development

    Author : Laura Waldmann; Tatjana Haitina; Abigail Tucker; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nkx3.2; Gdf5; zebrafish; jaw joint; joints; axial skeleton; appendicular skeleton; fin; enhancer conservation; CRISPR Cas9; OPT;

    Abstract : The vertebrate skeleton is composed of bony and cartilaginous structures that are developed under the control of numerous genetic networks. The transcription factor Nkx3. READ MORE

  6. 19. Identification and Functional Significance of Aberrant Long Non-coding RNAs in Acute Myeloid Leukemia : Biological and Prognostic Implications

    Author : Anne H. Neddermeyer; Sören Lehmann; Jonas Larsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia AML ; hematopoiesis; long non-coding RNAs lncRNAs ; RNA- and CAGE-sequencing; CRISPRi; CRISPR-Cas9; NEAT1; APL; NPM1; IDH2; all-trans retinoic acid; arsenic trioxide; venetoclax; drug resistance and sensitivity; prognosis; RADICL-sequencing; Molekylär medicin; Molecular Medicine;

    Abstract : Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It commonly affects people aged 60 or older, as incidence increases with age, and it is characterized by the accumulation of immature hematopoietic progenitor cells in the bone marrow. READ MORE

  7. 20. Optical Mapping of Bacterial Plasmids

    Author : Vilhelm Müller; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; competitive binding; optical mapping; fluorescence microscopy; DNA; plasmids; CRISPR Cas9; antibiotic resistance; nanofluidics; single-molecule;

    Abstract : Bacteria that have acquired resistance to antibiotics represent one of the largest threats to human health and modern health care. The genes encoding resistance are frequently spread via the transfer of plasmids, which are circular double stranded DNA molecules separate from the chromosomal DNA of the bacteria. READ MORE