Search for dissertations about: "CRM1"

Showing result 1 - 5 of 8 swedish dissertations containing the word CRM1.

  2. 1. Nucleoporins and Protein Transport in Drosophila

    Author : Peggy Roth; Christos Samakovlis; Volker Cordes; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NPC; Nucleoporin; Nup88; Nup214; CRM1; Dorsal; Drosophila; Developmental biology; Utvecklingsbiologi;

    Abstract : Many biological responses rely on the selective translocation of transcriptional regulators in and out of the nucleus through nuclear pore complexes (NPC). More than one million macromolecules per minute pass through the NPC and an important challenge is to understand the coordination of nucleocytoplasmic trafficking. READ MORE

  4. 2. Functional study of Nucleoporins Nup88 and Nup214 during Drosophila Development

    Author : Nikos Xylourgidis; Christos Samakovlis; Valerie Doye; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mbo; Nup88; CAN; Nup214; NPC; CRM1; embargoed; NF-kB; REL; Dorsal; Dif; Drosophila; Developmental biology; Utvecklingsbiologi;

    Abstract : More than a million macromolecules per minute pass through the nuclear envelope of a eukaryotic cell. An important challenge is to understand how the NPC coordinate efficiently the bi-directional trafficking necessary for the basal cellular activities and the rapid translocation of regulatory proteins in response to signaling. READ MORE

  5. 3. Understanding the role of long non-coding RNAs in neuroblastoma development and progression

    Author : Sanhita Mitra; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Long non-coding RNAs; NBAT1; NRSF REST; CASC15; chromosome 6p22; SOX9; USP36; CHD7; p53; CRM1; MDM2;

    Abstract : Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to NB tumor formation. READ MORE

  6. 4. Regulation of transcription factors by XAP-2 : a member of the Hsp90 chaperone complex

    Author : Petra Berg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The AhR belongs to the bHLH/PAS family of transcription factors, which mediates biological effects of environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD). In the absence of ligand the AhR is located in the cytoplasmatic compartment of the cell associated with the molecular chaperone Hsp90, p23 and a member of the immunophilin family of proteins, XAP-2. READ MORE

  7. 5. Molecular Cloning and Functional Characterization of Factors Involved in Post-transcriptional Gene Expression

    Author : Shao-Bo Jin; Lars Wieslander; Maria Carmo-Fonseca; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; gene expression; pre-mRNA processing; pre-rRNA processing; Molecular biology; Molekylärbiologi;

    Abstract : Gene expression in the eukaryotic cell is a fundamental cellular process, which consists of several distinct steps but extensively coupled to each other. From site of transcription in the nucleus to the cytoplasm, both mRNA and rRNA are associated with a proper set of proteins. READ MORE