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Showing result 1 - 5 of 10 swedish dissertations matching the above criteria.

  2. 1. On cerebrospinal fluid markers of HIV-1 infection

    Author : Lars-Magnus Andersson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; cerebrospinal fluid; AIDS dementia complex; ganglioside GD3; Tau proteins; neopterin; HIV-1 RNA; blood-brain barrier; albumin ratio; cultivation;

    Abstract : HIV-1 infects the central nervous system early in the course of infection and neurological complications are common in HIV-1-infected individuals. Approximately 20% of individuals with acquired immunodeficiency syndrome (AIDS) not treated with antiretroviral therapy develop a subcortical dementia, AIDS dementia complex (ADC). READ MORE

  4. 2. HIV-1 infection of the central nervous system. Markers of pathogenesis and antiretroviral treatment effects

    Author : Sahra Abdulle; Göteborgs universitet; []
    Keywords : HIV-1; cerebrospinal fluid; antiretroviral therapy; neopterin; beta2-microglobulin; CSF HIV-1 RNA; blood-brain barrier; IgG index; HIV-related neurological diseases; AIDS Dementia Complex; neurofilament protein; HIV-1 genetic subtypes;

    Abstract : Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the course of infection and either directly or through opportunistic infections causes a spectrum of neurological complications. The most severe manifestation of HIV-1 CNS infection is AIDS Dementia Complex (ADC), which occurs in approximately 20% of untreated patients with AIDS. READ MORE

  5. 3. Antiretroviral treatment of HIV-1 in the central nervous system

    Author : Aylin Yilmaz; Göteborgs universitet; []
    Keywords : HIV-1; cerebrospinal fluid; antiretroviral treatment; lopinavir; saquinavir; nelfinavir; neopterin; beta-2-microglobulin; HIV-1 RNA; IgG index; blood-brain barrier; albumin ratio; ultra-ultra sensitive PCR;

    Abstract : HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will develop neurological complications, caused by opportunistic pathogens or HIV-1 itself. READ MORE

  6. 4. On HIV-1 latency and viral reservoirs

    Author : Tomas Mellberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; Latency; Intravenous immunoglobulin; residual viremia; low level viremia; Ultrasensitive PCR methods; Central nervous system;

    Abstract : HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and anatomical reservoirs. This thesis concerns several problematic issues of HIV-1 persistence, including ways to measure and monitor both the virus at low viral concentrations and the depletion of the reservoir. READ MORE

  7. 5. On HIV-1 infection in the central nervous system

    Author : Åsa Mellgren; Göteborgs universitet; []
    Keywords : HIV-1; antiretroviral therapy; cerebrospinal fluid; neurofilament protein; AIDS dementia complex; neuropsychological test;

    Abstract : HIV-1 (hereafter referred to as HIV) is a neurotropic virus that invades the central nervous system (CNS). The CNS is then susceptible to an acute infection and later to CNS opportunistic diseases and AIDS dementia complex (ADC). HIV does not infect the neurons, and neuropathogenesis is largely mediated by the immune system. READ MORE