Search for dissertations about: "CTLA-4"

Showing result 11 - 15 of 54 swedish dissertations containing the word CTLA-4.

  2. 11. Immunogenetic studies of multiple sclerosis

    Author : Arturs Ligers; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multiple sclerosis; CTLA-4; HLA-A2; HLA-A3; HLA-DRB1*15; HLA-DRB1*;

    Abstract : Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS). Several genetic factors are likely to be of importance for MS rather than one factor. READ MORE

  4. 12. T lymphocytes in Wegener’s granulomatosis

    Author : Ricardo Antonio Giscombe Stephen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Wegener s granulomatosis; T lymphocytes; TCR; T cell expansions; HLA-DRB1*0401; CTLA-4; IL-10;

    Abstract : Wegener's granulomatosis (WG) is a systemic necrotizing vasculitis that affects small and medium size blood vessels. The respiratory tract and lungs are usually compromised with necrotizing granulomatous formations. The aetiology is unknown and untreated the prognosis of generalised WG is very poor. READ MORE

  5. 13. Molecular Mechanisms of Graves' Ophthalmopathy. A focus on smoking and radioiodine

    Author : Bushra Shahida; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Graves’ disease. Graves’ ophthalmopathy; radioiodine; inflammation; adipogenesis; IL-1ß; IL-6; PTGS2 COX2; PGE2; CTLA-4; B lymphocytes; T lymphocytes; Simvastatin; Diclofenac; SNP; gene expression; IGF-1;

    Abstract : Graves’ disease (GD) is an autoimmune disease characterized by hyperthyroidism and is caused by an interplayof genetic and environmental factors. One-third of patients with GD develop Graves’ ophthalmopathy (GO). Keyprocesses in the pathogenesis of GO are inflammation and adipogenesis in orbital tissue. READ MORE

  6. 14. Genetic and immunological control of human myasthenia gravis

    Author : Xiaoyan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myasthenia Gravis MG ; beta2-adrenergic receptor beta2-AR ; CCR2; CCR5; cytolytic T lymphocyte-associated antigen-4 CTLA-4 ; OX40;

    Abstract : Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular junction. Because of the involvement of multiple factors in the disease, the overall aims of this thesis were to uncover the regulation of candidate genes and the possible cellular mechanisms involved in the immuno-regulation of human MG. READ MORE

  7. 15. Immune profile from high-risk to onset of Type 1 diabetes

    Author : Anna Rydén; Maria Faresjö; Johnny Ludvigsson; Malin Flodström-Tullberg; Linköpings universitet; []
    Keywords : ;

    Abstract : Type 1 diabetes (T1D) is most often diagnosed early in life and is usually the result of an autoimmune attack on the insulin producing β-cells of the pancreas, leading to a lack of insulin secretion and life-long insulin treatment. The search for possible targets pin-pointing the β-cell destruction is a constant endeavour in the pursuit to prevent T1D onset. READ MORE