Search for dissertations about: "CTLA4Ig"

Showing result 1 - 5 of 7 swedish dissertations containing the word CTLA4Ig.

  2. 1. Induction of operational tolerance to allografts and xenografts

    Author : Matthias Corbascio; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; allograft; xenograft; heart transplantation; tolerance; anti-LFA-1; CTLA4Ig; anti-CD40L;

    Abstract : Inhibition of the costimulatory molecules B7 and CD40L with CTLA4Ig and anti-CD40L administered only during the first week after transplantation induces indefinite survival of allo- and xenogeneic heart transplants and significantly prolongs skin grafts in C3H mice. However, this treatment protocol is not as effective in C57BL/6 mice which reject skin transplants with nearly the same median survival time as untreated controls. READ MORE

  4. 2. Costimulation Blockade in Experimental Transplantation

    Author : Helene Malm; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi; serologi; Immunologi; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; graft survival; anti-CD40L; CTLA4Ig; anti-LFA-1; costimulation blockade;

    Abstract : Transplantation is the only cure for end-stage organ failure. With the transplantation follows the need for continuous treatment with immunosuppressive agents for as long as the graft functions, which entails major side effects. Less toxic treatments are therefore in great demand. Preferably, the treatment should also be limited in time. READ MORE

  5. 3. Cell transplantation with human mesenchymal or embryonic stem cells to the heart : experimental, molecular, immunological and echocardiographic studies

    Author : Karl-Henrik Grinnemo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Human mesenchymal stem cells; human embryonic stem cells; human cardiomyocyte; Islet-1; Nkx2.5; stem cell; xenotransplantation; rejection; FoxP3 T-cells; tolerance; CTLA4Ig; anti- CD40L; LFA-1;

    Abstract : Background: Human mesenchymal stem cells (hMSC), human embryonic stem cells (HESC) and human fetal cardiomyocyte progenitor cells (HFCP) all represent possible candidate cells for regeneration of damaged myocardium. Although they represent cell types with many positive attributes, their capacity to engraft, to differentiate into mature cardiomyocytes, to improve myocardial function and their immunological properties are the focus of these studies. READ MORE

  6. 4. Immunosuppresive properties of new potential drugs in transplantation

    Author : Clara Paul; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Transplantation of vital organs is today a widely used treatment when failure of the organ is a fact. To prevent rejection immunosuppresive treatment must be maintained lifelong, unless transplantation is perfomed between identical twins. READ MORE

  7. 5. Experimental islet transplantation

    Author : Randa A Hadi Gadalla Diab; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Pancreatic islet transplantation is a promising treatment modality for patients with insulin- dependent diabetes. Besides whole pancreas transplantation, it is the only treatment that can make patients normoglycemic without risking episodes of hypoglycemia. READ MORE