Search for dissertations about: "CXCL10"

Showing result 21 - 25 of 43 swedish dissertations containing the word CXCL10.

  2. 21. Cancer associated fibroblasts and T cells in pancreatic cancer : an immune perspective

    Author : Laia Gorchs; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : About 90% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC) and its deadly hallmarks, including a prominent fibrotic stroma, low mutational burden, lack of early diagnosis and rapid metastasis, contribute to trial failures and to the poor five-year overall survival rate of only 9%. Carcinoma associated fibroblasts (CAFs) are the most abundant cell type in the stroma of PDAC and their interactions with tumor cells leading to tumor progression have been extensively studied. READ MORE

  4. 22. Endothelial activation and inflammation in the tumor microenvironment

    Author : Hua Huang; Anna Dimberg; William C. Aird; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor angiogenesis; endothelial activation; leukocyte recruitment; VEGF-A; αB-crystallin; ELTD1;

    Abstract : Tumors are composed not only of malignant cells, but also of various types of normal cells, including vascular cells and infiltrating immune cells, which drive tumor development and progression. The tumor vasculature is abnormal and dysfunctional due to sustained tumor angiogenesis driven by high levels of pro-angiogenic factors. READ MORE

  5. 23. A stargazer's guide to neurodegeneration : Astrocytes' role in the propagation of pathological proteins

    Author : Tobias Mothes; Anna Erlandsson; Martin Ingelsson; Linn Streubel-Gallasch; Maria Grazia Spillantini; Uppsala universitet; []
    Keywords : Alzheimer’s disease; Parkinson’s disease; tauopathies; astrocyte; microglia; neuron; tau; amyloid-β; α-synuclein; accumulation; degradation; inflammation; spreading; seeding.; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of pathogenic protein aggregates. In the AD brain, amyloid-β (Aβ) and tau form plaques respective tangles, while in the PD brain α-synuclein (α-syn) form Lewy bodies and Lewy neurites. READ MORE

  6. 24. Neoehrlichiosis - latent infection of endothelium and immune defense

    Author : Linda Wass; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neoehrlichia mikurensis; neoehrlichiosis; human; infectious disease; endothelial cell; T cell;

    Abstract : This thesis is a study of the tick-borne pathogen Neoehrlichia (N.) mikurensis that causes the infectious disease neoehrlichiosis in humans. The disease affects both individuals with competent and suppressed immune defense with the majority of the affected being immunosuppressed. READ MORE

  7. 25. Pediatric Autoinflammatory Diseases: Conceptual, Clinical, and Mechanistic Dimensions

    Author : Per Wekell; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; child; fever; inflammation; cytokines; familial Mediterranean; neutrophils;

    Abstract : This thesis focuses on three paediatric autoinflammatory diseases in Sweden today; familial Mediterranean fever (FMF), periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) and synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO). In addition to describing autoinflammation with reference to these diseases, the thesis explores the concept of autoinflammatory disease by examining four existing definitions. READ MORE