Search for dissertations about: "CYP19"

Found 5 swedish dissertations containing the word CYP19.

  2. 1. Azoles and Contaminants in Treated Effluents Interact with CYP1 and CYP19 in Fish

    Author : Kristina Beijer; Ingvar Brandt; Björn Brunström; Henner Hollert; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Azole; fungicide; chemical; CYP1A; CYP19; EROD; aromatase; effluent; STP; wastewater; fish; stickleback; rainbow trout; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Abstract : Numerous contaminants are present in mixtures in the aquatic environment. Among these are the azoles, a group of chemicals that includes both pharmaceuticals and pesticides. Azole fungicides are designed to inhibit lanosterol 14-demethylase (cytochrome P450 (CYP) 51), while other azoles are intended to inhibit aromatase (CYP19), i.e. READ MORE

  4. 2. The Xenopus tropicalis model for developmental endocrine and reproductive toxicity : Histological and molecular endpoints for disrupted spermatogenesis

    Author : Sofie Svanholm; Cecilia Berg; Oskar Karlsson; Valérie Langlois; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Endocrine disrupting chemicals; Reproductive toxicology; Developmental toxicology; Spermatogenesis; Transgenerational; Xenopus tropicalis; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Abstract : Endocrine disrupting chemicals (EDCs) are linked to adverse effects in both humans and wildlife. There are however, large knowledge gaps regarding cause-effect and dose-response relationships between the interference with endocrine pathways and adverse effects in the organism, especially at puberty and in subsequent generations. READ MORE

  5. 3. Modulation of nuclear receptor signaling by RBR ubiquitin ligases

    Author : Nina Gustafsson Sheppard; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nuclear receptors (NRs) constitute a superfamily of transcription factors and play important roles in physiology. Transcriptional regulation by NRs can be modulated through interactions with various coregulators that activate or repress transcription through mediating receptor and chromatin modifications as well as communicating with the general transcription factor machinery. READ MORE

  6. 4. Studies of hyperandrogenicity and the metabolic syndrome in premenopausal women

    Author : Fariba Baghaei; Göteborgs universitet; []
    Keywords : androgens; SHBG; HPA axis; abdominal obesity; insulin; HDL; metabolic syndrome; ovarian volume; PCOS; polymorphism; genetics; androgen receptor; estrogen receptor; aromatase;

    Abstract : An androgenic sex hormone profile appears to be a typical feature of the metabolic syndrome (MetS) and a powerful risk factor for the development of type 2 diabetes in women. The causes of relative hyperandrogenicity (HA) are not clearly defined. READ MORE

  7. 5. Transcriptional regulation by the nuclear receptors steroidogenic factor-1 and liver receptor homologue-1

    Author : Anna Ehrlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Steroidogenic Factor-1 (SF-1) and Liver Receptor Homologue-1 (LRH-1) are transcription factors belonging to the nuclear receptor (NR) family. In the adrenal cortex and gonads, SF-1 governs the expression of multiple enzymes and transporters required for converting cholesterol to steroid hormones. READ MORE