Search for dissertations about: "CYP2C9"
Showing result 1 - 5 of 27 swedish dissertations containing the word CYP2C9.
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1. Computational Modelling of Structures and Ligands of CYP2C9
Abstract : CYP2C9 is one of our major drug metabolising enzymes and belongs to the cytochrome P450 (CYP) super family. The aim of this thesis was to gain an understanding of the quantitative structure–activity relationships (QSAR) of CYP2C9 substrates and inhibitors. READ MORE
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2. On the Prediction of Warfarin Dose
Abstract : Warfarin is one of the most widely used anticoagulants in the world. Treatment is complicated by a large inter-individual variation in the dose needed to reach adequate levels of anticoagulation i.e. INR 2. READ MORE
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3. Genetic polymorphisms in breast cancer in relation to risk and prognosis
Abstract : Breast cancer is the most common cancer in women living in Sweden and the second most common cancer in the rest of the world. The risk of developing breast cancer is modified by environment, lifestyle, genetics and a combination of these factors. READ MORE
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4. First-pass Intestinal Metabolism of Drugs : Experiences from in vitro, in vivo and simulation studies
Abstract : The bioavailability of a drug can be described as the fraction of an orally administered dose that reaches the systemic circulation and is often limited by first-pass metabolism in the gut and the liver. It is important to have knowledge about these processes since the systemic blood drug concentration is tightly connected to the effect of the drug. READ MORE
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5. CYP2C19 and CYP2C9 : new aspects of pharmacogenetics and transcriptional regulation
Abstract : Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to significantly affect the individual drug response. READ MORE